Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 6/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | PHGDH | O43175 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6533981 | 1.00 | HDAC3 (0.61) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6461106 | 0.85 | HDAC3 (0.64) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6470934 | 0.84 | HDAC3 (0.62) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6461129 | 0.84 | HDAC3 (0.62) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6454685 | 0.84 | HDAC3 (0.67) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6454613 | 0.82 | HDAC3 (0.59) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6455995 | 0.82 | NR1H4 (0.66) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL5566017 | 0.79 | HDAC1 (0.56) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6455555 | 0.79 | ACACB (0.57) | HDAC3HDAC4HDAC1HDAC6LMNA | |
| SCHEMBL5046595 | 0.77 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC6HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575933-A1 | ENANTIOMERS OF THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-21 | — | — | EP | claimed |
| WO-2004054999-A1 | ENANTIOMERS OF THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-01 | — | — | WO | claimed |
| EP-1575933-A1 | ENANTIOMERS OF THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004054999-A1 | ENANTIOMERS OF THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-01 | — | — | WO | disclosed |