Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | MAOB | P27338 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | MAOA | P21397 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358452 | 1.00 | CYP1A2 (0.73) | CYP1A2CYP2C9MAOBMEN1KMT2A | |
| SCHEMBL4398128 | 0.86 | NPSR1 (0.55) | CYP1A2CYP2C9MAOBSMN1; SMN2CYP2D6 | |
| SCHEMBL31553466 | 0.85 | CYP1A2 (1.00) | CYP1A2CYP2C9MAOBMEN1KMT2A | |
| SCHEMBL5598566 | 0.85 | CYP1A2 (1.00) | CYP1A2CYP2C9MAOBMEN1KMT2A | |
| SCHEMBL22596713 | 0.85 | CYP1A2 (0.79) | CYP1A2CYP2C9MAOBMEN1KMT2A | |
| SCHEMBL5598564 | 0.85 | CYP1A2 (1.00) | CYP1A2CYP2C9MAOBMEN1KMT2A | |
| 3-Chloro-Cinnamic Acid SCHEMBL22396853 | 0.83 | CYP1A2 (0.76) | CYP1A2CYP2C9MAOBMEN1KMT2A | |
| 3-Chloro-Cinnamic Acid SCHEMBL79592 | 0.83 | CYP1A2 (0.76) | CYP1A2CYP2C9MAOBMEN1KMT2A | |
| SCHEMBL1556592 | 0.83 | CYP1A2 (0.76) | CYP1A2CYP2C9MAOBMEN1KMT2A | |
| 3-Chloro-Cinnamic Acid SCHEMBL79591 | 0.83 | CYP1A2 (0.76) | CYP1A2CYP2C9MAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1217943-C | New use and novel N-azabicyclo-amide derivatives | ASTRAZENECA AB (SE) | 2005-09-07 | — | — | CN | claimed |
| CN-1423651-A | Novel use and novel N-azabicyclo-amide derivatives | ASTRAZENECA AB (SE) | 2003-06-11 | — | — | CN | claimed |
| US-20240382482-A1 | PLASMA KALLIKREIN INHIBITORS | TAKEDA PHARMACEUTICALS CO (JP) | 2024-11-21 | — | — | US | disclosed |
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| CN-117396474-A | Plasma kallikrein inhibitors | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| CN-109836383-B | Method for preparing 3, 4-dihydroquinoline-2 (1H) -ketone compound | 安徽理工大学 | 2022-04-19 | — | — | CN | disclosed |
| CN-104418762-B | A kind of method from aldehyde synthesizing amide | 南京理工大学 | 2016-12-28 | — | — | CN | disclosed |
| CN-104418682-B | A kind of method from oxime synthesizing amide | NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-03-23 | — | — | CN | disclosed |
| CN-104418762-A | Method for synthesizing amides from aldehyde | UNIV NANJING SCIENCE & TECH | 2015-03-18 | — | — | CN | disclosed |
| CN-104418682-A | Method for synthesizing amides from oxime | UNIV NANJING SCIENCE & TECH | 2015-03-18 | — | — | CN | disclosed |
| US-RE36625-E | Linear and cyclic polymers or oligomers having a photoreactive ethene group | ROLIC AG (CH) | 2000-03-21 | — | — | US | disclosed |
| CN-1049224-C | Polymers as alignment layer | ROLIC AG (CH) | 2000-02-09 | — | — | CN | disclosed |
| CN-1241176-A | Prevention of loss and restoration of bone mass by certain prostaglandin agonists | PFIZER (US) | 2000-01-12 | — | — | CN | disclosed |
| EP-0946501-A1 | PREVENTION OF LOSS AND RESTORATION OF BONE MASS BY CERTAIN PROSTAGLANDIN AGONISTS | PFIZER INC. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1999019300-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 1999-04-22 | — | — | WO | disclosed |
| WO-1998028264-A1 | PREVENTION OF LOSS AND RESTORATION OF BONE MASS BY CERTAIN PROSTAGLANDIN AGONISTS | PFIZER INC. (US) | 1998-07-02 | — | — | WO | disclosed |
| US-5539074-A | LIQUID CRYSTAL POLYMERS ON SILICA FOR LIGHT SENSITIVE ELEMENTS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-23 | — | — | US | disclosed |
| CN-1091458-A | Polymkeric substance as oriented layer | HOFFMANN LA ROCHE (CH) | 1994-08-31 | — | — | CN | disclosed |
| US-4012377-A | ANTIMICROBIAL, PARASITICIDES | GLAXO LABORATORIES LIMITED (EN) | 1977-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240382482-A1 | PLASMA KALLIKREIN INHIBITORS | KLKB1, KLK5, KLK1 | CYP1A2 2901/4885CYP2C9 2202/4885MAOB 1691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.