Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28417972 | 0.99 | KMT2A (0.54) | KMT2AMEN1NPSR1AGBL2ALDH1A1 | |
| Acetic Acid SCHEMBL28393632 | 0.92 | KMT2A (0.53) | KMT2AMEN1NPSR1AGBL2ALDH1A1 | |
| SCHEMBL31255260 | 0.89 | TDP1 (0.58) | KMT2AMEN1NPSR1ALDH1A1HTT | |
| SCHEMBL635541 | 0.89 | TDP1 (0.58) | KMT2AMEN1NPSR1ALDH1A1HTT | |
| Acetic Acid SCHEMBL4444086 | 0.89 | KMT2A (0.53) | KMT2AMEN1NPSR1AGBL2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6157878 | 0.88 | TDP1 (0.56) | KMT2AMEN1NPSR1ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL637924 | 0.88 | TDP1 (0.56) | KMT2AMEN1NPSR1ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL16165936 | 0.88 | TDP1 (0.56) | KMT2AMEN1NPSR1ALDH1A1HTT | |
| Sulfuric Acid SCHEMBL18191278 | 0.87 | KMT2A (0.56) | KMT2AMEN1NPSR1ALDH1A1HTT | |
| Water SCHEMBL28174658 | 0.86 | TDP1 (0.55) | KMT2AMEN1NPSR1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478365-A | Purification method of 2-aminomethyl-3-chloro-5-trifluoromethylpyridine acetate | 大连九信作物科学有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-111170934-B | Dissociation method of 2-aminomethyl-3-chloro-5-trifluoromethyl pyridine nickel acetate complex | 大连九信精细化工有限公司 | 2021-07-13 | — | — | CN | claimed |
| CN-111170934-A | Dissociation method of 2-aminomethyl-3-chloro-5-trifluoromethyl pyridine nickel acetate complex | 大连九信精细化工有限公司 | 2020-05-19 | — | — | CN | claimed |
| CN-111138351-A | Synthetic method of 2-aminomethyl-3-chloro-5-trifluoromethylpyridine acetate | 大连九信精细化工有限公司 | 2020-05-12 | — | — | CN | claimed |
| CN-111372919-B | Method for preparing fluopicolide | 拜耳公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-115784976-A | Improved preparation method of fluopicolide | 武威广达科技有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-114478365-A | Purification method of 2-aminomethyl-3-chloro-5-trifluoromethylpyridine acetate | 大连九信作物科学有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-114478365-A | Purification method of 2-aminomethyl-3-chloro-5-trifluoromethylpyridine acetate | 大连九信作物科学有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-114478365-A | Purification method of 2-aminomethyl-3-chloro-5-trifluoromethylpyridine acetate | 大连九信作物科学有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-11130735-B2 | Process for the preparation of fluopicolide | BAYER AKTIENGESELLSCHAFT | 2021-09-28 | — | — | US | disclosed |
| CN-111170934-B | Dissociation method of 2-aminomethyl-3-chloro-5-trifluoromethyl pyridine nickel acetate complex | 大连九信精细化工有限公司 | 2021-07-13 | — | — | CN | disclosed |
| US-20200283388-A1 | PROCESS FOR THE PREPARATION OF FLUOPICOLIDE | BAYER AKTIENGESELLSCHAFT (DE) | 2020-09-10 | — | — | US | disclosed |
| CN-111138351-A | Synthetic method of 2-aminomethyl-3-chloro-5-trifluoromethylpyridine acetate | 大连九信精细化工有限公司 | 2020-05-12 | — | — | CN | disclosed |
| EP-3489221-A1 | PROCESS FOR THE PREPARATION OF FLUOPICOLIDE | Bayer AG (DE) | 2019-05-29 | — | — | EP | disclosed |
| US-7456290-B2 | Process for the preparation of 2-aminomethylpyridine derivative | BAYER CROPSCIENCE S.A. (FR) | 2008-11-25 | — | — | US | disclosed |
| EP-1565440-B1 | NOVEL PROCESS FOR THE PREPARATION OF 2-AMINOMETHYLPYRIDINE DERIVATIVE | BAYER CROPSCIENCE SA (FR) | 2006-12-20 | — | — | EP | disclosed |
| US-20060004206-A1 | Novel process for the preparation of 2-aminomethylpyridine derivative | BAYER CROPSCIENCE S.A. (FR) | 2006-01-05 | — | — | US | disclosed |
| EP-1565440-A1 | NOVEL PROCESS FOR THE PREPARATION OF 2-AMINOMETHYLPYRIDINE DERIVATIVE | Bayer CropScience S.A. (FR) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004046114-A1 | NOVEL PROCESS FOR THE PREPARATION OF 2-AMINOMETHYLPYRIDINE DERIVATIVE | BAYER CROPSCIENCE S.A. (FR) | 2004-06-03 | — | — | WO | disclosed |
| EP-1422221-A1 | Novel process for the preparation of 2-aminomethylpyridine derivative | Bayer CropScience SA (FR) | 2004-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004206-A1 | Novel process for the preparation of 2-aminomethylpyridine derivative | AZI2, IL4I1, ABL2 | KMT2A 457/4885MEN1 2177/4885NPSR1 1747/4885 |
| US-11130735-B2 | Process for the preparation of fluopicolide | HCN4, KCNJ1, CYP51A1 | KMT2A 1500/4885MEN1 3049/4885NPSR1 2335/4885 |
| US-20200283388-A1 | PROCESS FOR THE PREPARATION OF FLUOPICOLIDE | HCN4, KCNJ1, CYP51A1 | KMT2A 1500/4885MEN1 3049/4885NPSR1 2335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.