Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048117 | 0.93 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2AMEN1HSD17B10ALDH1A1 | |
| SCHEMBL2601402 | 0.89 | SMN1; SMN2 (0.61) | SMN1; SMN2KMT2AMEN1HSD17B10 | |
| SCHEMBL5043233 | 0.83 | RAB9A (0.49) | SMN1; SMN2 | |
| SCHEMBL21583731 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL25987654 | 0.80 | POLB (0.60) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL5048100 | 0.80 | TAS2R14 (0.64) | KMT2AMEN1HSD17B10ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL5109987 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2KMT2AMEN1HSD17B10ALDH1A1 | |
| SCHEMBL6059400 | 0.79 | RAB9A (0.52) | SMN1; SMN2KMT2AMEN1HSD17B10ALDH1A1 | |
| SCHEMBL17084609 | 0.79 | HDAC1 (0.70) | SMN1; SMN2KMT2AMEN1HSD17B10 | |
| SCHEMBL5047945 | 0.78 | TAS2R14 (0.58) | SMN1; SMN2KMT2AMEN1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1021410-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999019300-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 1999-04-22 | — | — | WO | disclosed |