Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044108 | 0.88 | MAPT (0.40) | PPARDPPARAMAPTRAB9ANPC1 | |
| SCHEMBL5043889 | 0.88 | CDC25A (0.43) | MAPTRAB9ANPC1POLBPLA2G2A | |
| SCHEMBL5047852 | 0.82 | PPARD (0.45) | PPARDPPARAMAPTRAB9ANPC1 | |
| SCHEMBL5045076 | 0.81 | MAPT (0.40) | PPARDPPARAMAPTRAB9ANPC1 | |
| SCHEMBL4427086 | 0.79 | PLA2G2A (0.42) | RAB9ANPC1L3MBTL1PLA2G2AGAA | |
| SCHEMBL4416088 | 0.79 | PLA2G2A (0.42) | RAB9ANPC1L3MBTL1PLA2G2AGAA | |
| SCHEMBL5043686 | 0.78 | HPGD (0.42) | PPARDPPARAMAPTRAB9ANPC1 | |
| SCHEMBL5048735 | 0.78 | CDC25A (0.45) | PPARDPPARAMAPTRAB9ANPC1 | |
| SCHEMBL5048642 | 0.78 | CDC25A (0.44) | MAPTRAB9ANPC1POLBPLA2G2A | |
| SCHEMBL5039634 | 0.77 | MAPT (0.39) | PPARDPPARAMAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583762-B1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | claimed |