Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048888 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2ATSHRMEN1HTT | |
| SCHEMBL1852104 | 0.87 | KMT2A (0.50) | SMN1; SMN2KMT2ATSHRMEN1HTT | |
| SCHEMBL5048907 | 0.79 | GUSB (0.44) | AKR1C3EPHX2 | |
| SCHEMBL1853214 | 0.78 | TSHR (0.43) | SMN1; SMN2KMT2ATSHRMEN1HTT | |
| SCHEMBL4020745 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2ATSHRALDH1A1LMNA | |
| SCHEMBL4714622 | 0.76 | TSHR (0.56) | SMN1; SMN2KMT2ATSHRMEN1HTT | |
| SCHEMBL1856431 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2ATSHRMEN1HTT | |
| SCHEMBL4022476 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2KMT2ATSHRMEN1HTT | |
| SCHEMBL6719223 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2ATSHRMEN1HTT | |
| SCHEMBL4715831 | 0.75 | TSHR (0.60) | SMN1; SMN2KMT2ATSHRMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |