Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 3/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1854510 | 0.89 | LPAR1 (0.45) | GUSBPGRNR3C1AKR1C3LPAR1 | |
| SCHEMBL5047516 | 0.79 | SMN1; SMN2 (0.54) | AKR1C3EPHX2 | |
| SCHEMBL1855180 | 0.76 | MAPK14 (0.43) | GUSBPGRNR3C1AKR1C3LTA4H | |
| SCHEMBL4020754 | 0.76 | MAPK14 (0.42) | GUSBPGRNR3C1AKR1C3LTA4H | |
| SCHEMBL4715421 | 0.72 | ALDH1A1 (0.46) | GUSBAKR1C3LTA4HEPHX2 | |
| SCHEMBL4715423 | 0.72 | ALDH1A1 (0.50) | GUSBAKR1C3EPHX2 | |
| SCHEMBL5048888 | 0.72 | SMN1; SMN2 (0.53) | EPHX2 | |
| SCHEMBL1857604 | 0.71 | CASR (0.40) | AKR1C3 | |
| SCHEMBL4713555 | 0.70 | MAPK14 (0.41) | GUSBPGRNR3C1AKR1C3LTA4H | |
| SCHEMBL1852104 | 0.69 | KMT2A (0.50) | AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |