Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.70 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.70 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.70 |
| ▸ | FGB | P02675 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | PLEC | Q15149 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.66 |
| ▸ | UQCRB | P14927 | 2/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5943960 | 0.95 | MEN1 (0.66) | MEN1KMT2APSMD14POLBMAPT | |
| SCHEMBL15480538 | 0.91 | MEN1 (0.71) | MEN1KMT2AHDAC8HDAC6HDAC3 | |
| SCHEMBL10093054 | 0.87 | GPR55 (0.69) | MEN1KMT2APSMD14POLBMAPT | |
| SCHEMBL5048564 | 0.86 | UQCRB (0.71) | MEN1KMT2APSMD14POLBMAPT | |
| SCHEMBL15482013 | 0.86 | HDAC8 (0.71) | MEN1KMT2APOLBMAPTHDAC8 | |
| SCHEMBL5943909 | 0.86 | HDAC8 (0.65) | MEN1KMT2APSMD14POLBMAPT | |
| SCHEMBL15480542 | 0.82 | HDAC3 (0.69) | MEN1KMT2APOLBMAPTCYP2C9 | |
| SCHEMBL15480530 | 0.82 | HDAC6 (0.74) | MEN1KMT2AMAPTHDAC8HDAC6 | |
| SCHEMBL15480558 | 0.82 | HDAC8 (0.74) | MEN1KMT2AMAPTCYP2C9NPSR1 | |
| SCHEMBL15480539 | 0.82 | HDAC3 (0.74) | MEN1KMT2APOLBMAPTHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146623-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2008-06-19 | — | — | US | disclosed |
| US-RE39850-E1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | METHYLGENE, INC. (CA) | 2007-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146623-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | HDAC1, HDAC3, HDAC11 | MEN1 1848/4885KMT2A 36/4885PSMD14 2685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.