Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12319715 | 0.85 | BCL2L1 (0.56) | HDAC3HDAC1HDAC4HDAC6BCL2L1 | |
| SCHEMBL5565647 | 0.81 | HDAC3 (0.54) | HDAC3HDAC1HDAC4HDAC6BCL2L1 | |
| SCHEMBL6412727 | 0.79 | BCL2L1 (0.64) | HDAC3HDAC1HDAC4HDAC6BCL2L1 | |
| SCHEMBL2412288 | 0.78 | HDAC1 (0.65) | HDAC3HDAC1HDAC4HDAC6BCL2L1 | |
| SCHEMBL2406496 | 0.78 | HDAC1 (0.65) | HDAC3HDAC1HDAC4HDAC6BCL2L1 | |
| SCHEMBL2411536 | 0.70 | TAS1R3 (0.50) | HDAC3HDAC1HDAC4HDAC6BCL2L1 | |
| SCHEMBL2411538 | 0.70 | TAS1R3 (0.50) | HDAC3HDAC1HDAC4HDAC6BCL2L1 | |
| SCHEMBL5046183 | 0.69 | HDAC6 (0.48) | HDAC3HDAC1HDAC4HDAC6 | |
| SCHEMBL6455051 | 0.68 | HDAC3 (0.57) | HDAC3HDAC1HDAC4HDAC6CYP2C9 | |
| SCHEMBL9502722 | 0.68 | ALOX5 (0.59) | ALOX5CYP1A2PTGESLMNALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396944-B2 | Thiophene derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2008-07-08 | — | — | US | claimed |
| EP-1778683-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-02 | — | — | EP | claimed |
| WO-2005121134-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1778683-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-02 | — | — | EP | disclosed |
| WO-2005121134-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | disclosed |