SCHEMBL5048243

SCHEMBL5048243

c1ccc2c(c1)Cc1cc(COCc3ccc4c(c3)Cc3ccccc3-4)ccc1-2

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.54
ALDH1A1 P00352 2/20 0.54
ATM Q13315 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
NPC1 O15118 3/20 0.53
RAB9A P51151 3/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
TP53 P04637 1/20 0.53
MAPK1 P28482 1/20 0.53
KDM4E B2RXH2 1/20 0.52
LMNA P02545 1/20 0.52
MAPT P10636 1/20 0.52
HPGD P15428 1/20 0.52
CYP17A1 P05093 1/20 0.50
GPR84 Q9NQS5 1/20 0.49
SRD5A2 P31213 1/20 0.46
HTT P42858 1/20 0.46
PDE10A Q9Y233 1/20 0.44
CYP1A2 P05177 3/20 0.44
CYP3A4 P08684 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24277978 0.86 TSHR (0.49) TSHRALDH1A1ATMNPSR1NPC1
SCHEMBL7195015 0.82 GPR84 (0.60) TSHRALDH1A1ATMNPSR1NPC1
SCHEMBL598903 0.82 TSHR (0.58) TSHRALDH1A1ATMNPSR1NPC1
SCHEMBL1903359 0.82 GPR84 (0.50) TSHRALDH1A1ATMNPSR1NPC1
SCHEMBL1903357 0.82 TSHR (0.48) TSHRALDH1A1ATMNPSR1NPC1
SCHEMBL9610283 0.82 TSHR (0.51) TSHRALDH1A1ATMNPSR1NPC1
SCHEMBL1609629 0.80 TSHR (0.53) TSHRALDH1A1ATMNPSR1NPC1
SCHEMBL2965416 0.79 TSHR (0.55) TSHRALDH1A1ATMNPSR1NPC1
SCHEMBL5357579 0.79 ALDH1A1 (0.59) TSHRALDH1A1ATMNPSR1NPC1
SCHEMBL18536625 0.79 TSHR (0.55) TSHRALDH1A1ATMNPSR1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7445825-B2 Donor sheet having a polymerizable, amorphous matrix with electrically active material disposed therein 3M INNOVATIVE PROPERTIES COMPANY (US) 2008-11-04 US disclosed
US-20060008577-A1 Method and materials for patterning of a polymerizable, amorphous matrix with electrically active material disposed therein 3M INNOVATIVE PROPERTIES COMPANY 2006-01-12 US disclosed
EP-1417866-A1 METHOD AND MATERIALS FOR PATTERNING OF A POLYMERIZABLE, AMORPHOUS MATRIX WITH ELECTRICALLY ACTIVE MATERIAL DISPOSED THEREIN 3M Innovative Properties Company (US) 2004-05-12 EP disclosed
US-20030064248-A1 A transfer layer containing said matrix with a light emitting material is solution coated on a donor substrate, a portion of the transfer layer is selectively thermally transferred to a receptor and then the matrix is polymerized SAMSUNG DISPLAY CO., LTD. (KR) 2003-04-03 US disclosed
WO-2003017732-A1 METHOD AND MATERIALS FOR PATTERNING OF A POLYMERIZABLE, AMORPHOUS MATRIX WITH ELECTRICALLY ACTIVE MATERIAL DISPOSED THEREIN 3M INNOVATIVE PROPERTIES COMPANY (US) 2003-02-27 WO disclosed