SCHEMBL5048528

SCHEMBL5048528

Cc1c(N2C(=O)C=CC2=O)c(=O)oc2cccc(N(C)C)c12

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.35
KDM4E B2RXH2 3/20 0.35
MAPT P10636 2/20 0.35
MGLL Q99685 4/20 0.33
CCR4 P51679 3/20 0.33
HSP90AA1 P07900 1/20 0.33
EP300 Q09472 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
USP2 O75604 1/20 0.32
POLB P06746 1/20 0.32
ALDH1A1 P00352 1/20 0.31
MMP2 P08253 1/20 0.31
MMP13 P45452 1/20 0.31
FAAH O00519 1/20 0.31
TSHR P16473 1/20 0.31
NQO1 P15559 1/20 0.30
PGR P06401 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28131701 0.75 KDM4E (0.50) GAAKDM4EMAPTMGLLMEN1
SCHEMBL29527262 0.71 CCR4 (0.64) GAAKDM4EMAPTCCR4EP300
SCHEMBL179796 0.71 CCR4 (0.64) GAAKDM4EMAPTCCR4EP300
SCHEMBL5565883 0.69 CCR4 (0.36) GAAKDM4EMAPTCCR4HSP90AA1
SCHEMBL1518273 0.67 EP300 (0.62) GAAKDM4EMAPTMGLLHSP90AA1
SCHEMBL1509342 0.67 MAPT (0.58) GAAKDM4EMAPTMEN1KMT2A
SCHEMBL4393558 0.67 GAA (0.51) GAAKDM4EMAPTMEN1KMT2A
SCHEMBL3611550 0.66 EDNRA (0.59) GAAKDM4EMAPTMEN1KMT2A
SCHEMBL29693028 0.65 KDM4E (0.46) GAAKDM4EMAPTALDH1A1TSHR
SCHEMBL13701010 0.64 GAA (0.44) GAAKDM4EMEN1KMT2AUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7357864-B2 Microfluidic device KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) 2008-04-15 US disclosed
US-7238325-B2 Very small chemical device and flow rate adjusting method therefor KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) 2007-07-03 US disclosed
US-7220334-B2 Method of manufacturing microdevice having laminated structure KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) 2007-05-22 US disclosed
US-20060091051-A1 Micro fluid device and process for producing the same KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) 2006-05-04 US disclosed
US-20030190265-A1 Very small chemical device and flow rate adjusting method therefor KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) 2003-10-09 US disclosed
US-20030175162-A1 Microdevice having multilayer structure and method for fabricating the same KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) 2003-09-18 US disclosed
EP-1327474-A1 VERY SMALL CHEMICAL DEVICE AND FLOW RATE ADJUSTING METHOD THEREFOR KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) 2003-07-16 EP disclosed
EP-1295846-A1 MICRODEVICE HAVING MULTILAYER STRUCTURE AND METHOD FOR FABRICATING THE SAME KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) 2003-03-26 EP disclosed