SCHEMBL5048829

SCHEMBL5048829

NC(=O)c1cc(Cl)cc(C(N)=O)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 5/20 0.60
TPMT P51580 1/20 0.52
HCAR1 Q9BXC0 1/20 0.44
ADRA1D P25100 1/20 0.44
CYP3A4 P08684 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
MAP4K4 O95819 2/20 0.42
MKNK1 Q9BUB5 1/20 0.42
MKNK2 Q9HBH9 1/20 0.42
DHODH Q02127 2/20 0.42
POLB P06746 1/20 0.42
MAPT P10636 1/20 0.42
TSHR P16473 1/20 0.42
CYP2C19 P33261 1/20 0.42
RECQL P46063 1/20 0.42
BLM P54132 1/20 0.42
PMP22 Q01453 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL349820 0.94 PARP1 (0.60) PARP1TPMTHCAR1ADRA1DCYP3A4
Hydrochloric Acid SCHEMBL4371939 0.92 PARP1 (0.58) PARP1TPMTHCAR1ADRA1DCYP3A4
SCHEMBL14060424 0.90 PARP1 (0.56) PARP1TPMTHCAR1ADRA1DCYP3A4
SCHEMBL16952186 0.89 PARP1 (0.50) PARP1TPMTHCAR1ADRA1DCYP3A4
SCHEMBL4339312 0.85 HCAR1 (0.65) PARP1TPMTHCAR1ADRA1DCYP3A4
SCHEMBL813450 0.85 PARP1 (0.53) PARP1CYP3A4SMN1; SMN2DHODHPOLB
SCHEMBL9631667 0.84 PARP1 (0.50) PARP1TPMTHCAR1ADRA1DCYP3A4
SCHEMBL22383502 0.84 PARP1 (0.50) PARP1TPMTHCAR1ADRA1DMAP4K4
SCHEMBL30463182 0.84 PARP1 (0.50) PARP1TPMTHCAR1ADRA1DCYP3A4
SCHEMBL1363329 0.84 PARP1 (0.50) PARP1TPMTHCAR1ADRA1DCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1914221-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-04-23 EP disclosed