Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049034 | 0.86 | PPARG (0.44) | SPHK1 | |
| SCHEMBL5044913 | 0.82 | HTR2A (0.43) | HDAC1HDAC8 | |
| SCHEMBL1853070 | 0.82 | HDAC1 (0.43) | HDAC1HDAC2HDAC8SIRT2SPHK1 | |
| SCHEMBL1855651 | 0.82 | HDAC1 (0.43) | HDAC1HDAC2HDAC8SIRT2SPHK1 | |
| SCHEMBL5044951 | 0.82 | SPHK1 (0.41) | HDAC1HDAC2HDAC8SIRT2KMT2A | |
| SCHEMBL1850427 | 0.81 | HDAC1 (0.37) | HDAC1HDAC2HDAC8SIRT2KMT2A | |
| SCHEMBL1850428 | 0.81 | L3MBTL1 (0.54) | HDAC1HDAC2HDAC8SIRT2KMT2A | |
| SCHEMBL1855887 | 0.76 | L3MBTL1 (0.36) | HDAC1HDAC2HDAC8KMT2AL3MBTL1 | |
| SCHEMBL1855520 | 0.76 | PLK1 (0.40) | HDAC1HDAC2HDAC8KMT2AL3MBTL1 | |
| SCHEMBL1854119 | 0.76 | PLK1 (0.40) | HDAC1HDAC2HDAC8KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |