Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1855651 | 0.87 | HDAC1 (0.43) | SPHK1HDAC1HDAC2HDAC8SIRT2 | |
| SCHEMBL1853070 | 0.87 | HDAC1 (0.43) | SPHK1HDAC1HDAC2HDAC8SIRT2 | |
| SCHEMBL1850427 | 0.85 | HDAC1 (0.37) | SPHK1HDAC1HDAC2HDAC8SIRT2 | |
| SCHEMBL1850428 | 0.85 | L3MBTL1 (0.54) | SPHK1HDAC1HDAC2HDAC8SIRT2 | |
| SCHEMBL6783418 | 0.84 | NPC1 (0.47) | SPHK1OPRL1PPARA | |
| SCHEMBL5048947 | 0.82 | HDAC1 (0.35) | SPHK1HDAC1HDAC2HDAC8SIRT2 | |
| SCHEMBL5045622 | 0.82 | FAAH (0.48) | HDAC1HDAC8PLK1 | |
| SCHEMBL5048334 | 0.82 | FAAH (0.48) | HDAC1HDAC8PLK1 | |
| SCHEMBL4966332 | 0.80 | FAAH (0.49) | HDAC1HDAC8PLK1 | |
| SCHEMBL1854119 | 0.80 | PLK1 (0.40) | HDAC1HDAC2HDAC8L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |
| EP-1732534-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | Applied Research Systems ARS Holding N.V. (AN) | 2006-12-20 | — | — | EP | claimed |
| WO-2005082347-A1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | APLLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-09-09 | — | — | WO | claimed |
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | disclosed |