SCHEMBL5049491

SCHEMBL5049491

CC1CN(CC2CCN(C)CC2)CC(C)N1C(C=O)[S+]([O-])C(c1ccccc1)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA2D1 P54289 1/20 0.43
CACNA1B Q00975 1/20 0.43
CACNB1 Q02641 1/20 0.43
CACNA1C Q13936 1/20 0.43
SIGMAR1 Q99720 2/20 0.33
CYP2D6 P10635 2/20 0.33
SLC6A2 P23975 2/20 0.33
SLC6A3 Q01959 2/20 0.33
CHRM2 P08172 1/20 0.33
HTR1A P08908 1/20 0.33
ADRA2A P08913 1/20 0.33
CHRM1 P11229 1/20 0.33
DRD1 P21728 1/20 0.33
ADRA1A P35348 1/20 0.33
OPRM1 P35372 1/20 0.33
DRD3 P35462 1/20 0.33
KCNH2 Q12809 1/20 0.33
HRH3 Q9Y5N1 1/20 0.33
CYP1A2 P05177 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5051949 0.88 TACR2 (0.37) CACNA2D1CACNA1BCACNB1CACNA1CCYP2D6
SCHEMBL4277158 0.76 CACNA2D1 (0.52) CACNA2D1CACNA1BCACNB1CACNA1CSLC6A2
SCHEMBL3394232 0.68 CACNA2D1 (0.52) CACNA2D1CACNA1BCACNB1CACNA1CSLC6A3
SCHEMBL4275822 0.67 CACNA2D1 (0.69) CACNA2D1CACNA1BCACNB1CACNA1CCHRM1
SCHEMBL22564969 0.66 NCF1 (0.43) CACNA2D1CACNA1BCACNB1CACNA1CSIGMAR1
SCHEMBL2791272 0.65 CACNA2D1 (0.62) CACNA2D1CACNA1BCACNB1CACNA1CCHRM1
SCHEMBL5048006 0.65 CACNA1G (0.38) CYP2D6CHRM2OPRM1
SCHEMBL5140493 0.64 CACNA2D1 (0.49) CACNA2D1CACNA1BCACNB1CACNA1CSLC6A2
SCHEMBL4271169 0.64 TACR2 (0.43) CACNA2D1CACNA1BCACNB1CACNA1CCYP2D6
SCHEMBL2791008 0.63 CACNA2D1 (0.46) CACNA2D1CACNA1BCACNB1CACNA1CLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1976841-A1 HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS Neuromed Pharmaceuticals, Ltd. (CA) 2008-10-08 EP claimed
WO-2007071035-A1 HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS NEUROMED PHARMACEUTICALS LTD. (CA) 2007-06-28 WO claimed
EP-1976841-A1 HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS Neuromed Pharmaceuticals, Ltd. (CA) 2008-10-08 EP disclosed
WO-2007071035-A1 HETEROCYCLIC AMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS NEUROMED PHARMACEUTICALS LTD. (CA) 2007-06-28 WO disclosed