Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.37 |
| ▸ | ACLY | P53396 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6363387 | 1.00 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28628083 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28518559 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL29242813 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7784258 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4728788 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1900557 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5606548 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4728791 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28827380 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309775-B1 | EXHAUST SYSTEM FOR ENHANCED REDUCTION OF NITROGEN OXIDES AND PARTICULATES FROM DIESEL ENGINES | BASF CATALYSTS LLC (US) | 2008-06-18 | — | — | EP | disclosed |
| US-7143578-B2 | Exhaust system for enhanced reduction of nitrogen oxides and particulates from diesel engines | ENGELHARD CORPORATION (US) | 2006-12-05 | — | — | US | disclosed |
| US-7055311-B2 | Emission control system for vehicles powered by diesel engines | ENGELHARD CORPORATION (US) | 2006-06-06 | — | — | US | disclosed |
| US-20050113249-A1 | Using platinum and ceria; low temperature combustion of soot | ZIEBARTH ROBIN (US) | 2005-05-26 | — | — | US | disclosed |
| US-20050056004-A1 | A combined system of catalyzed soot filters for particulate matter reduction and urea selective catalytic reduction catalysts for NOx reduction; ultra low emission standards | ENGELHARD CORPORATION | 2005-03-17 | — | — | US | disclosed |
| US-6826906-B2 | Exhaust system for enhanced reduction of nitrogen oxides and particulates from diesel engines | ENGELHARD CORPORATION | 2004-12-07 | — | — | US | disclosed |
| WO-2004020807-A1 | EMISSION CONTROL SYSTEM FOR VEHICLES POWERED BY DIESEL ENGINES | ENGELHARD CORPORATION (US) | 2004-03-11 | — | — | WO | disclosed |
| US-20040040287-A1 | Emission control system for vehicles powered by diesel engines | ENGELHARD CORPORATION | 2004-03-04 | — | — | US | disclosed |
| EP-1309775-A1 | EXHAUST SYSTEM FOR ENHANCED REDUCTION OF NITROGEN OXIDES AND PARTICULATES FROM DIESEL ENGINES | Engelhard Corporation (US) | 2003-05-14 | — | — | EP | disclosed |
| US-20020044897-A1 | Aftertreatment uses catalyzed soot filters and urea selective catalytic reduction (SCR) to lower particulates and nitrogen oxide (NOx) at the same time; ultra low emission standards | ENGELHARD CORPORATION | 2002-04-18 | — | — | US | disclosed |
| WO-2002014657-A1 | EXHAUST SYSTEM FOR ENHANCED REDUCTION OF NITROGEN OXIDES AND PARTICULATES FROM DIESEL ENGINES | ENGELHARD CORPORATION (US) | 2002-02-21 | — | — | WO | disclosed |