Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.37 |
| ▸ | ACLY | P53396 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL29144186 | 0.96 | ALDH1A1 (0.65) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL29242813 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1900557 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28518559 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4728791 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4728788 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL6363387 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5606548 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5049508 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28827380 | 0.95 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110487867-B | Quantitative detection method of T4 polynucleotide kinase | 中国科学院苏州生物医学工程技术研究所 | 2022-03-08 | — | — | CN | claimed |
| CN-110487867-A | The quantitative detecting method of T4 polynueleotide kinase | SUZHOU INST BIOMEDICAL ENG & TECH CAS | 2019-11-22 | — | — | CN | claimed |
| CN-115172693-A | Neutral silver-zinc battery positive electrode material and preparation method thereof, and neutral silver-zinc battery | 深圳大学 | 2022-10-11 | — | — | CN | disclosed |
| CN-110487867-B | Quantitative detection method of T4 polynucleotide kinase | 中国科学院苏州生物医学工程技术研究所 | 2022-03-08 | — | — | CN | disclosed |
| CN-109449409-B | Preparation method of ternary material | 郭庆平 | 2021-08-06 | — | — | CN | disclosed |
| CN-108084583-B | Preparation method of graphene and preparation of sound insulation graphene EPS | 吉林云亭石墨烯技术股份有限公司 | 2021-01-01 | — | — | CN | disclosed |
| US-20200130066-A1 | PHOTOCHEMICAL SYNTHESIS OF DENDRITIC SILVER PARTICLES | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY | 2020-04-30 | — | — | US | disclosed |
| CN-110487867-A | The quantitative detecting method of T4 polynueleotide kinase | SUZHOU INST BIOMEDICAL ENG & TECH CAS | 2019-11-22 | — | — | CN | disclosed |
| CN-108084583-A | A kind of preparation method of graphene and its preparation of sound insulation graphene EPS | 吉林云亭石墨烯技术股份有限公司 | 2018-05-29 | — | — | CN | disclosed |
| EP-0672120-B1 | PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES ACTIVE AGAINST HEPATITIS B SURFACE ANTIGEN | SANDOZ LTD (CH) | 2001-10-17 | — | — | EP | disclosed |
| US-6004562-A | IMMUNOGENS FOR VACCINE FORMULATIONS, AND AS ANTIGENS IN DIAGNOSTIC IMMUNOASSAYS | THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK (US) | 1999-12-21 | — | — | US | disclosed |
| WO-1998006432-A1 | OUTER MEMBRANE PROTEIN B1 OF MORAXELLA CATARRHALIS | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1998-02-19 | — | — | WO | disclosed |
| US-5648077-A | MONOCLONAL ANTIBODIES AND BINDING TO HEPATITIS B AND ANTIGENS | SANDOZ LTD. (CH) | 1997-07-15 | — | — | US | disclosed |
| US-5565354-A | FOR DIAGNOSIS AND TREATMENT OF DISEASES CAUSED BY INFECTION WITH HEPATITIS B VIRUS | SANDOZ LTD. (CH) | 1996-10-15 | — | — | US | disclosed |
| EP-0672120-A4 | PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES ACTIVE AGAINST HEPATITIS B SURFACE ANTIGEN. | SANDOZ LTD (CH) | 1996-09-11 | — | — | EP | disclosed |
| EP-0672120-A1 | PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES ACTIVE AGAINST HEPATITIS B SURFACE ANTIGEN | SANDOZ LTD. (CH) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994011495-A1 | PRODUCTION OF HUMAN MONOCLONAL ANTIBODIES ACTIVE AGAINST HEPATITIS B SURFACE ANTIGEN | SANDOZ, LTD. (CH) | 1994-05-26 | — | — | WO | disclosed |