Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | CLK3 | P49761 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4587956 | 1.00 | DYRK3 (0.41) | DYRK3KMT2APOLBMEN1DOT1L | |
| Trifluoroacetic Acid SCHEMBL2993058 | 0.92 | DOT1L (0.37) | DYRK3KMT2APOLBMEN1DOT1L | |
| Trifluoroacetic Acid SCHEMBL2993055 | 0.92 | DOT1L (0.37) | DYRK3KMT2APOLBMEN1DOT1L | |
| SCHEMBL2992654 | 0.83 | ALOX5 (0.36) | DYRK3KMT2APOLBMEN1MAPT | |
| SCHEMBL2992651 | 0.83 | ALOX5 (0.36) | DYRK3KMT2APOLBMEN1MAPT | |
| SCHEMBL2993031 | 0.79 | DYRK3 (0.50) | DYRK3KMT2AMEN1MAPTHTT | |
| SCHEMBL2993030 | 0.79 | DYRK3 (0.50) | DYRK3KMT2AMEN1MAPTHTT | |
| SCHEMBL4148685 | 0.79 | CLK1 (0.53) | DYRK3KMT2APOLBMEN1MAPT | |
| SCHEMBL2993698 | 0.79 | CLK1 (0.53) | DYRK3KMT2APOLBMEN1MAPT | |
| SCHEMBL2993704 | 0.79 | CLK1 (0.53) | DYRK3KMT2APOLBMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214455-A1 | Novel Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214455-A1 | Novel Chemical Compounds | HIPK3, HIPK1, HIPK4 | DYRK3 1471/4885KMT2A 3294/4885POLB 3047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.