Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 14/20 | 0.58 |
| ▸ | CA1 | P00915 | 14/20 | 0.58 |
| ▸ | CA2 | P00918 | 14/20 | 0.58 |
| ▸ | CA4 | P22748 | 14/20 | 0.58 |
| ▸ | CA9 | Q16790 | 14/20 | 0.58 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.56 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046385 | 0.90 | CA12 (0.61) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5046710 | 0.88 | PTGER2 (0.51) | CA12CA1CA2CA4CA9 | |
| SCHEMBL27490133 | 0.88 | TAS2R14 (0.56) | PTGER2TAS2R14 | |
| SCHEMBL4947305 | 0.88 | CA12 (0.75) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5046671 | 0.87 | CA12 (0.72) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5049462 | 0.86 | CA12 (0.61) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5050517 | 0.85 | PTGER2 (0.56) | CA12CA1CA2CA4CA9 | |
| SCHEMBL27522148 | 0.84 | TAS2R14 (0.50) | PTGER2TAS2R14 | |
| SCHEMBL5726684 | 0.84 | CA12 (0.67) | CA12CA1CA2CA4CA9 | |
| SCHEMBL5046427 | 0.84 | CA12 (0.58) | CA12CA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |