Tetrahydrofuran

Tetrahydrofuran

SCHEMBL5050358

C1CCOC1.CC(=O)N(C)C

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
MAPT P10636 2/20 0.39
SMN1; SMN2 Q16637 3/20 0.37
PIK3CD O00329 1/20 0.35
TSHR P16473 1/20 0.32
MEN1 O00255 1/20 0.31
TP53 P04637 1/20 0.31
KMT2A Q03164 1/20 0.31
PKM P14618 1/20 0.30
KDM4E B2RXH2 1/20 0.30
NPC1 O15118 1/20 0.30
MITF O75030 1/20 0.30
LMNA P02545 1/20 0.30
PTBP1 P26599 1/20 0.30
HTT P42858 1/20 0.30
RECQL P46063 1/20 0.30
KDM4C Q9H3R0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrofuran SCHEMBL8503112 1.00 ALDH1A1 (0.44) ALDH1A1MAPTSMN1; SMN2PIK3CDTSHR
SCHEMBL1346214 0.97 ALDH1A1 (0.42) ALDH1A1MAPTSMN1; SMN2PIK3CDTSHR
Tetrahydrofuran SCHEMBL9439653 0.89 TSHR (0.39) ALDH1A1MAPTSMN1; SMN2PIK3CDTSHR
Dioxane SCHEMBL1346219 0.88 SMN1; SMN2 (0.46) ALDH1A1MAPTSMN1; SMN2PIK3CDTSHR
SCHEMBL9105112 0.83 ALDH1A1 (0.32) ALDH1A1MAPTTSHR
Tetrahydrofuran SCHEMBL18064960 0.83 ALDH1A1 (0.44) ALDH1A1MAPTSMN1; SMN2TSHRMEN1
Tetrahydrofuran SCHEMBL165529 0.82
Tetrahydrofuran SCHEMBL11690381 0.79 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2PIK3CDTSHRMEN1
Dioxane SCHEMBL10806051 0.79 ALDH1A1 (0.53) ALDH1A1MAPTSMN1; SMN2TSHRMEN1
Tetrahydrofuran SCHEMBL1704980 0.79 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2PIK3CDTSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11485925-B2 Lubricous silicone CARDIAC PACEMAKERS, INC. (US) 2022-11-01 US claimed
EP-3880265-A1 LUBRICOUS SILICONE Cardiac Pacemakers, Inc. (US) 2021-09-22 EP claimed
WO-2020102480-A1 LUBRICOUS SILICONE CARDIAC PACEMAKERS, INC. (US) 2020-05-22 WO claimed
US-20200157455-A1 LUBRICOUS SILICONE CARDIAC PACEMAKERS, INC. 2020-05-21 US claimed
CN-105023767-B A kind of preparation method of electrode material 中国第汽车股份有限公司 2018-06-01 CN claimed
WO-2013156200-A1 PROCESS FOR PRODUCING (ETHYNE-1,2-DIYL)BIS(ISOBENZOFURAN-1,3- DIONE) NEXAM CHEMICAL AB (SE) 2013-10-24 WO claimed
EP-2653467-A1 Process for producing (ethyne-1,2-diyl)bis(isobenzofuran-1,3- dione) Nexam Chemical AB (SE) 2013-10-23 EP claimed
US-7166690-B2 Recycled method for a wasted polyester and reclaimed materials thereof SAMSUNG ELECTRONICS CO., LTD. (KR) 2007-01-23 US claimed
US-20050203277-A1 Recycled method for a wasted polyester and reclaimed materials thereof KIM, DO-GYUN (KR) 2005-09-15 US claimed
US-11485925-B2 Lubricous silicone CARDIAC PACEMAKERS, INC. (US) 2022-11-01 US disclosed
CN-114177744-B Trapezoidal polymer with micropores for gas separation, membrane and application 中国气象科学研究院 2022-04-15 CN disclosed
CN-114177744-A Trapezoidal polymer with micropores for gas separation, membrane and application 中国气象科学研究院 2022-03-15 CN disclosed
WO-2022049604-A1 PROCESS FOR PREPARING REVEFENACIN AND INTERMEDIATES THEROF CIPLA LIMITED (IN) 2022-03-10 WO disclosed
EP-3880265-A1 LUBRICOUS SILICONE Cardiac Pacemakers, Inc. (US) 2021-09-22 EP disclosed
WO-2002010244-A2 BIOCIDAL POLYURETHANE COMPOSITIONS AND METHOD OF USE 3M INNOVATIVE PROPERTIES COMPANY (US) 2002-02-07 WO disclosed
EP-0171410-A1 A BODY TISSUE REPLACEMENT PRODUCT AND A METHOD OF PRODUCING THE PRODUCT MEDINVENT S.A. (CH) 1986-02-19 EP disclosed
WO-1985003444-A1 A BODY TISSUE REPLACEMENT PRODUCT AND A METHOD OF PRODUCING THE PRODUCT MEDINVENT S. A. (CH) 1985-08-15 WO disclosed
US-4371686-A POLYETHERURETHANE COPOLYMER AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY MINISTRY OF INTERNATIONAL TRADE & INDUSTRY (JP) 1983-02-01 US disclosed
EP-0032991-A1 Reversible electrochromic display device International Business Machines Corporation (US) 1981-08-05 EP disclosed
US-4226980-A ANTIBIOTICS, BACTERICIDES ABBOTT LABORATORIES (US) 1980-10-07 US disclosed