Tetrahydrofuran

Tetrahydrofuran

SCHEMBL9439653

C1CCOC1.CC(=O)N(C)C.CN(C)C=O

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.39
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.31
PIK3CD O00329 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dioxane SCHEMBL16719050 0.91 TSHR (0.43) TSHRMAPTSMN1; SMN2PIK3CD
Tetrahydrofuran SCHEMBL23295002 0.91 TSHR (0.43) TSHRALDH1A1MAPTSMN1; SMN2
Tetrahydrofuran SCHEMBL8503112 0.89 ALDH1A1 (0.44) TSHRALDH1A1MAPTSMN1; SMN2PIK3CD
Tetrahydrofuran SCHEMBL5050358 0.89 ALDH1A1 (0.44) TSHRALDH1A1MAPTSMN1; SMN2PIK3CD
Dimethylformamide SCHEMBL6550357 0.87 TSHR (0.39) TSHRALDH1A1SMN1; SMN2
Tetrahydrofuran SCHEMBL28212755 0.87 TSHR (0.39) TSHRALDH1A1SMN1; SMN2
Tetrahydrofuran SCHEMBL2439396 0.86 TSHR (0.47) TSHRALDH1A1
SCHEMBL1346214 0.86 ALDH1A1 (0.42) TSHRALDH1A1MAPTSMN1; SMN2PIK3CD
Tetrahydrofuran SCHEMBL129722 0.86 TSHR (0.53) TSHRALDH1A1
Tetrahydrofuran SCHEMBL28743802 0.84 TSHR (0.50) TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107987032-B Phenolic hydroxyl-containing amino acid-N-thiocarboxylic anhydride monomer and synthesis and polymerization method thereof 浙江大学 2020-10-30 CN claimed
CN-108467465-B Preparation method of graphene modified vinyl acetate-maleic anhydride copolymer flame-retardant leather retanning agent 四川大学 2020-06-12 CN disclosed
US-5294646-A N-alkyl-n-(meth)acryloyloxyalkylcarboxamides of aromatic carboxylic acids and aromatic carboxylic acid anhydrides, and adhesives containing these compounds BAYER AKTIENGESELLSCHAFT (DE) 1994-03-15 US disclosed
US-5241081-A N-ALKYL-N-(METH)ACRYLOYLOXYALKYLCARBOXAMIDES OF AROMATIC CARBOXYLIC ACIDS AND AROMATIC CARBOXYLIC ACID ANHYDRIDES, AND ADHESIVES CONTAINING THESE COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 1993-08-31 US disclosed