Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1544895 | 0.84 | ALDH1A1 (0.67) | ALDH1A1HSD17B10LMNAPOLBHPGD | |
| SCHEMBL1544475 | 0.84 | HSD17B10 (0.71) | ALDH1A1HSD17B10LMNATDP1POLB | |
| SCHEMBL5711682 | 0.72 | TDP1 (0.48) | ALDH1A1HSD17B10LMNATDP1POLB | |
| SCHEMBL10916439 | 0.70 | ALDH1A1 (1.00) | ALDH1A1HSD17B10TDP1HPGDKDM4E | |
| SCHEMBL974759 | 0.70 | ALDH1A1 (0.69) | ALDH1A1HSD17B10POLBHPGDKDM4E | |
| SCHEMBL919250 | 0.70 | HSD17B10 (0.73) | ALDH1A1HSD17B10LMNATDP1POLB | |
| SCHEMBL2328248 | 0.68 | HSD17B10 (0.60) | ALDH1A1HSD17B10LMNATDP1POLB | |
| SCHEMBL2496934 | 0.68 | NPC1 (0.73) | ALDH1A1LMNAPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL10915111 | 0.68 | ALDH1A1 (0.66) | ALDH1A1HSD17B10LMNATDP1HPGD | |
| SCHEMBL4172596 | 0.67 | ALDH1A1 (0.70) | ALDH1A1HSD17B10HPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934209-A1 | 5- (PHENYLISOXAZOLYLETHOXY) -TRIAZOL- 3 -YL SUBSTITUTED PYRIDINE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC OR PAIN DISORDERS | Astra Zeneca AB (SE) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007040982-A1 | 5- (PHENYLISOXAZOLYLETHOXY) -TRIAZOL- 3 -YL SUBSTITUTED PYRIDINE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL, PSYCHIATRIC OR PAIN DISORDERS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |