Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5050224 | 0.81 | RXFP1 (0.43) | RXFP1PIK3CDCRHR1MAPTKDM4E | |
| SCHEMBL5043225 | 0.81 | RXFP1 (0.40) | RXFP1PIK3CDCRHR1MAPTKDM4E | |
| SCHEMBL5049278 | 0.74 | KDM4E (0.37) | RXFP1CRHR1MAPTKDM4EL3MBTL1 | |
| SCHEMBL5799948 | 0.71 | L3MBTL1 (0.43) | RXFP1PIK3CDKDM4EL3MBTL1DRD4 | |
| SCHEMBL18259015 | 0.69 | SCN2A (0.45) | RXFP1PIK3CDMAPTKDM4EL3MBTL1 | |
| SCHEMBL5049263 | 0.67 | TACR1 (0.35) | RXFP1PIK3CD | |
| SCHEMBL18259019 | 0.66 | KDM4E (0.36) | RXFP1PIK3CDMAPTKDM4EL3MBTL1 | |
| SCHEMBL19178435 | 0.66 | KDM4E (0.46) | MAPTKDM4EKMT2ATDP1POLB | |
| SCHEMBL18259014 | 0.65 | MDM2 (0.33) | RXFP1PIK3CD | |
| SCHEMBL1229717 | 0.62 | KEAP1 (0.42) | MAPTATMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981342-B1 | SELECTIVE BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS | REDDYS LAB LTD DR (IN) | 2016-11-30 | — | — | EP | disclosed |
| EP-1981342-A1 | SELECTIVE BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS | Reddy US Therapeutics, Inc. (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007075194-A1 | SELECTIVE BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS | REDDY US THERAPEUTICS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |