Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 11/20 | 0.69 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413716 | 0.89 | FFAR1 (0.55) | LTA4HFFAR1HRH3 | |
| SCHEMBL5631841 | 0.87 | LTA4H (0.72) | LTA4HFFAR1KMT2A | |
| SCHEMBL5631838 | 0.87 | LTA4H (0.72) | LTA4HFFAR1KMT2A | |
| SCHEMBL4140738 | 0.85 | ABHD6 (0.54) | LTA4HFFAR1 | |
| SCHEMBL15811746 | 0.85 | ABHD6 (0.54) | LTA4HFFAR1 | |
| SCHEMBL2258523 | 0.84 | ABHD6 (0.54) | LTA4HKMT2A | |
| SCHEMBL28159876 | 0.84 | FFAR1 (0.53) | LTA4HFFAR1HRH3 | |
| SCHEMBL16468435 | 0.84 | LTA4H (0.49) | LTA4HHRH3 | |
| SCHEMBL13809008 | 0.84 | LTA4H (0.93) | LTA4HFFAR1 | |
| SCHEMBL4319104 | 0.83 | LTA4H (0.58) | LTA4HFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926708-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | Decode Chemistry, Inc. (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007040682-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF. (IS) | 2007-04-12 | — | — | WO | disclosed |