Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
| ▸ | CPA1 | P15085 | 1/20 | 0.30 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL717137 | 0.93 | TRPM8 (0.56) | TRPM8PTGS2 | |
| SCHEMBL716432 | 0.91 | TRPM8 (0.47) | TRPM8PTGS2S1PR3PTGS1MME | |
| SCHEMBL718091 | 0.90 | TRPM8 (0.47) | TRPM8PTGS2S1PR3PTGS1 | |
| SCHEMBL722135 | 0.89 | TRPM8 (0.52) | TRPM8PTGS2 | |
| SCHEMBL717484 | 0.88 | TRPM8 (0.45) | TRPM8S1PR3MMEACECPA1 | |
| SCHEMBL717609 | 0.87 | TRPM8 (0.49) | TRPM8PTGS2 | |
| SCHEMBL717281 | 0.87 | TRPM8 (0.49) | TRPM8PTGS2 | |
| SCHEMBL717818 | 0.85 | TRPM8 (0.43) | TRPM8S1PR3 | |
| SCHEMBL718029 | 0.85 | TRPM8 (0.43) | TRPM8S1PR3 | |
| SCHEMBL715490 | 0.85 | TRPM8 (0.47) | TRPM8PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897781-B2 | Cold menthol receptor-1 antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-01 | — | — | US | disclosed |
| US-20080027029-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027029-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | TRPM8 1/4885PTGS2 909/4885S1PR3 466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.