Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Flupirtine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 10/20 | 0.86 |
| ▸ | KCNQ3 | O43525 | 8/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.86 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.86 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.86 |
| ▸ | ESR1 | P03372 | 1/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | HTR1A | P08908 | 1/20 | 0.86 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.86 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.86 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.86 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.86 |
| ▸ | CASP1 | P29466 | 1/20 | 0.86 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.86 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flupirtine SCHEMBL505635 | 0.95 | KCNQ2 (0.88) | KCNQ2KCNQ3CYP1A2CYP2C9CYP2C19 | |
| Flupirtine SCHEMBL505513 | 0.94 | KCNQ2 (0.86) | KCNQ2KCNQ3CYP1A2CYP2C9CYP2C19 | |
| Flupirtine SCHEMBL505446 | 0.93 | KCNQ2 (0.96) | KCNQ2KCNQ3CYP1A2CYP2C9CYP2C19 | |
| Flupirtine SCHEMBL25009 | 0.93 | KCNQ2 (1.00) | KCNQ2KCNQ3CYP1A2CYP2C9CYP2C19 | |
| Flupirtine SCHEMBL29400613 | 0.93 | KCNQ2 (1.00) | KCNQ2KCNQ3CYP1A2CYP2C9CYP2C19 | |
| Flupirtine SCHEMBL3896230 | 0.93 | KCNQ2 (1.00) | KCNQ2KCNQ3CYP1A2CYP2C9CYP2C19 | |
| Flupirtine SCHEMBL15357226 | 0.93 | KCNQ2 (1.00) | KCNQ2KCNQ3CYP1A2CYP2C9CYP2C19 | |
| Flupirtine SCHEMBL505911 | 0.92 | KCNQ2 (0.94) | KCNQ2KCNQ3CYP1A2CYP2C9CYP2C19 | |
| Flupirtine SCHEMBL505608 | 0.92 | KCNQ2 (0.94) | KCNQ2KCNQ3CYP1A2CYP2C9CYP2C19 | |
| Flupirtine SCHEMBL505847 | 0.92 | KCNQ2 (0.98) | KCNQ2KCNQ3CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028930-A1 | FLUPIRTINE SALTS AND POLYMORPHS | BIONEVIA PHARMACEUTICALS INC. (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028930-A1 | FLUPIRTINE SALTS AND POLYMORPHS | SULT2A1, TACR1, NPSR1 | HDAC1 3455/4885KCNQ2 1153/4885KCNQ3 1107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.