Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 3/20 | 0.45 |
| ▸ | MDM4 | O15151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5050585 | 0.86 | CASP3 (0.53) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL5055624 | 0.86 | CASP3 (0.45) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL14586399 | 0.85 | CASP3 (0.49) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL13382809 | 0.85 | CASP3 (0.49) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL13863442 | 0.82 | MDM4 (0.46) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL8009538 | 0.81 | CASP3 (0.53) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL5051763 | 0.79 | MDM4 (0.44) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL18269836 | 0.79 | CASP3 (0.51) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL2439000 | 0.78 | MDM4 (0.50) | CASP3MDM4TP53KMT2AMDM2 | |
| SCHEMBL14456738 | 0.78 | MDM4 (0.47) | CASP3MDM4TP53KMT2AMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045507-B2 | Coumarin-based amino acids for use in enzyme activity and substrate specificity assays | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2015-06-02 | — | — | US | disclosed |
| EP-1946102-A1 | COUMARIN-BASED AMINO ACIDS FOR USE IN ENZYME ACTIVITY AND SUBSTRATE SPECIFICITY ASSAYS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2008-07-23 | — | — | EP | disclosed |
| US-20070031892-A1 | Novel coumarin-based amino acids for use in enzyme activity and substrate specificity assays | USC | 2007-02-08 | — | — | US | disclosed |
| WO-2007014326-A1 | COUMARIN-BASED AMINO ACIDS FOR USE IN ENZYME ACTIVITY AND SUBSTRATE SPECIFICITY ASSAYS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2007-02-01 | — | — | WO | disclosed |