Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.33 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.33 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.33 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 5/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054207 | 0.94 | CRHR1 (0.36) | CRHR1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5112576 | 0.89 | CRHR1 (0.41) | CRHR1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5055769 | 0.78 | CRHR1 (0.35) | CRHR1 | |
| SCHEMBL5055781 | 0.75 | CRHR1 (0.36) | CRHR1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5055775 | 0.75 | CRHR1 (0.36) | CRHR1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5054348 | 0.74 | CRHR1 (0.40) | CRHR1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5054202 | 0.68 | CRHR1 (0.39) | CRHR1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5054205 | 0.68 | CRHR1 (0.39) | CRHR1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5054127 | 0.67 | CRHR1 (0.44) | CRHR1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5052307 | 0.66 | CRHR1 (0.59) | CRHR1ARTRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446108-B2 | Tri-and tetraaza-acenaphthylen derivatives as CRF receptor antagonists | NEUROCRINE, INC. (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1392689-B1 | TRI- AND TETRAAZA-ACENAPHTHYLEN DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES INC (US) | 2006-10-25 | — | — | EP | disclosed |
| US-20040198726-A1 | Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198726-A1 | Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists | CRHR1, AGTR1, NPY1R | CRHR1 1/4885TUBB4A 3833/4885TUBB 3951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.