Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 10/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5483508 | 0.86 | PTAFR (0.51) | PTAFRMAPK1TLR7NAMPTUSP2 | |
| SCHEMBL5063706 | 0.84 | PDE4B (0.45) | L3MBTL1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7960463 | 0.81 | PDE4D (0.47) | MAPK1L3MBTL1PDE4APDE4BPDE4C | |
| SCHEMBL5056788 | 0.80 | PDE4B (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5063683 | 0.79 | PDE4D (0.38) | L3MBTL1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5056692 | 0.78 | PDE4B (0.46) | PTAFRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5063684 | 0.78 | BRD4 (0.38) | PDE4APDE4BPDE4CPDE4DROCK2 | |
| SCHEMBL5061811 | 0.77 | PDE4D (0.44) | L3MBTL1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5061814 | 0.77 | PDE4D (0.49) | L3MBTL1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5483471 | 0.77 | ROCK2 (0.45) | MAPK1TLR7NAMPTL3MBTL1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214536-A1 | Amido-Substituted 6-Phenylphenanthridines | NYCOMED GMBH (DE) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214536-A1 | Amido-Substituted 6-Phenylphenanthridines | PDE4A, PDE4B, PDE3A | PTAFR 1396/4885MAPK1 440/4885TLR7 2027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.