Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3604405 | 1.00 | HSD17B10 (0.41) | HSD17B10NPC1PIK3CASMN1; SMN2PIK3CD | |
| SCHEMBL3597539 | 0.84 | OPRM1 (0.36) | HSD17B10NPC1 | |
| SCHEMBL3597277 | 0.81 | DPP4 (0.46) | DPP4 | |
| SCHEMBL30388232 | 0.79 | HSD17B10 (0.44) | HSD17B10NPC1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL1907844 | 0.79 | HSD17B10 (0.44) | HSD17B10NPC1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL1903239 | 0.78 | KLK5 (0.42) | HSD17B10NPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL240483 | 0.76 | HSD17B10 (0.59) | HSD17B10NPC1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL2225858 | 0.76 | HSD17B10 (0.59) | HSD17B10NPC1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL239130 | 0.76 | HSD17B10 (0.59) | HSD17B10NPC1SMN1; SMN2LMNANPSR1 | |
| SCHEMBL2744394 | 0.75 | MEN1 (0.48) | SMN1; SMN2DPP4MEN1KMT2AACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919864-A2 | FAP INHIBITORS | Ferring B.V. (NL) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007085895-A2 | FAP INHIBITORS | FERRING B.V. (US) | 2007-08-02 | — | — | WO | disclosed |