Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | PEPD | P12955 | 2/20 | 0.36 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30388232 | 0.86 | HSD17B10 (0.44) | KLK5CA1CA2NPC1SMN1; SMN2 | |
| SCHEMBL1907844 | 0.86 | HSD17B10 (0.44) | KLK5CA1CA2NPC1SMN1; SMN2 | |
| SCHEMBL29689842 | 0.78 | CTSK (0.41) | CA1CA2HSD17B10CTSKBTK | |
| SCHEMBL3604405 | 0.78 | HSD17B10 (0.41) | KLK5CA1CA2NPC1SMN1; SMN2 | |
| SCHEMBL5056535 | 0.78 | HSD17B10 (0.41) | KLK5CA1CA2NPC1SMN1; SMN2 | |
| SCHEMBL29496710 | 0.76 | HSD17B10 (0.40) | FKBP1APOLBCA1CA2NPC1 | |
| SCHEMBL3413490 | 0.76 | CA1 (0.39) | CA1CA2CTSKBTKMEN1 | |
| SCHEMBL22887890 | 0.76 | CA1 (0.39) | CA1CA2CTSKBTKMEN1 | |
| SCHEMBL3411401 | 0.76 | CA1 (0.39) | CA1CA2CTSKBTKMEN1 | |
| SCHEMBL3411407 | 0.76 | CA1 (0.39) | CA1CA2CTSKBTKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316839-A1 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2011-05-04 | — | — | EP | disclosed |
| US-7642339-B2 | Hepatitis C; 1-benzyloxycarbonylamino-2-vinyl-cyclopropyl)-phenyl-phosphinic acid ethyl ester | GILEAD SCIENCES, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-20080311077-A1 | Antiviral Compounds | GILEAD SCIENCES, INC. | 2008-12-18 | — | — | US | disclosed |
| US-20060122123-A1 | Antiviral compounds | GILEAD SCIENCES, INC. | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080311077-A1 | Antiviral Compounds | EIF2AK2, MAVS, ITPA | KLK5 3630/4885FKBP1A 2074/4885POLB 46/4885 |
| US-20060122123-A1 | Antiviral compounds | EIF2AK2, MAVS, ITPA | KLK5 3630/4885FKBP1A 2074/4885POLB 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.