⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6303631 | 0.80 | TSHR (0.55) | — | |
| Succinic Acid SCHEMBL3039741 | 0.79 | LMNA (0.60) | — | |
| SCHEMBL23648 | 0.77 | — | — | |
| SCHEMBL2403116 | 0.77 | GRM8 (0.61) | — | |
| SCHEMBL11089864 | 0.74 | FOLH1 (0.52) | — | |
| Hydrochloric Acid SCHEMBL28145400 | 0.74 | FOLH1 (0.52) | — | |
| SCHEMBL9061995 | 0.74 | GRM8 (0.59) | — | |
| Ammonia Solution, Strong SCHEMBL28215144 | 0.74 | FOLH1 (0.52) | — | |
| Water SCHEMBL28860761 | 0.74 | FOLH1 (0.52) | — | |
| SCHEMBL8531618 | 0.73 | LMNA (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080317834-A1 | Compounds and methods for modulating cerebral amyloid angiopathy | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2008-12-25 | — | — | US | disclosed |
| US-6670399-B2 | Contacting a blood vessel wall cell with an A beta 40 inhibitor, such that cerebral amyloid angiopathy is inhibited | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2003-12-30 | — | — | US | disclosed |
| EP-1251837-A2 | COMPOUNDS AND METHODS FOR MODULATING CEREBRAL AMYLOID ANGIOPATHY | Neurochem, Inc. (CA) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001085093-A2 | COMPOUNDS AND METHODS FOR MODULATING CEREBRAL AMYLOID ANGIOPATHY | NEUROCHEM, INC. (US) | 2001-11-15 | — | — | WO | disclosed |