Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | USP2 | O75604 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17486069 | 0.97 | JAK2 (0.53) | JAK2JAK3PTK2ALDH1A1LMNA | |
| SCHEMBL17220118 | 0.91 | ALDH1A1 (0.61) | JAK2JAK3PTK2ALDH1A1LMNA | |
| SCHEMBL5064225 | 0.90 | ALDH1A1 (0.52) | JAK2JAK3PTK2ALDH1A1LMNA | |
| SCHEMBL5063368 | 0.89 | ALDH1A1 (0.50) | JAK2JAK3PTK2ALDH1A1LMNA | |
| SCHEMBL19300445 | 0.85 | ROCK1 (0.50) | JAK2JAK3PTK2ALDH1A1LMNA | |
| SCHEMBL5066683 | 0.82 | ALDH1A1 (0.43) | JAK2JAK3PTK2ALDH1A1LMNA | |
| SCHEMBL796470 | 0.81 | ROCK1 (0.51) | JAK2JAK3PTK2ALDH1A1LMNA | |
| SCHEMBL5058811 | 0.81 | SMN1; SMN2 (0.46) | JAK2JAK3PTK2ALDH1A1LMNA | |
| SCHEMBL5245431 | 0.78 | ROCK1 (0.63) | JAK2JAK3PTK2ALDH1A1LMNA | |
| SCHEMBL23576917 | 0.77 | TUBB4A (0.69) | JAK2JAK3PTK2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010085246-A1 | 2,4-DIAMINO-1,3,5-TRIAZINE AND 4, 6-DIAMINO-PYRIMIDINE DERIVATIVES AND THEIR USE AS AGGRECANASE INHIBITORS | PRAECIS PHARMACEUTICALS INC (US) | 2010-07-29 | — | — | WO | disclosed |
| US-20080146574-A1 | Heterocycle Substituted Carboxylic Acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2008-06-19 | — | — | US | disclosed |
| US-7329680-B2 | Heterocycle substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2008-02-12 | — | — | US | disclosed |
| EP-1844043-A2 | HETEROCYCLE SUBSTITUTED CARBOXYLIC ACIDS FOR THE TREATMENT OF DIABETES | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-10-17 | — | — | EP | disclosed |
| US-20060122222-A1 | Heterocycle substituted carboxylic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC | 2006-06-08 | — | — | US | disclosed |
| WO-2006055708-A2 | HETEROCYCLE SUBSTITUTED CARBOXYLIC ACIDS FOR THE TREATMENT OF DIABETES | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2006-05-26 | — | — | WO | disclosed |
| EP-1628970-A2 | HETEROCYCLE SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | The Institutes of Pharmaceutical Discovery, LLC (US) | 2006-03-01 | — | — | EP | disclosed |
| US-20050004114-A1 | Heterocycle substituted carboxylic acids | INSTITUTE FOR DIABETES DISCOVERY, L.L.C. | 2005-01-06 | — | — | US | disclosed |
| WO-2004099192-A2 | HETEROCYCLE SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | THE INSTITUTES OF PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004114-A1 | Heterocycle substituted carboxylic acids | PTPRC, PTPRS, PTPRJ | JAK2 43/4885JAK3 172/4885PTK2 365/4885 |
| US-20080146574-A1 | Heterocycle Substituted Carboxylic Acids | PTPRC, PTPRS, PTPRJ | JAK2 43/4885JAK3 172/4885PTK2 365/4885 |
| US-20060122222-A1 | Heterocycle substituted carboxylic acids | PTPRC, PTPRS, PTPRJ | JAK2 43/4885JAK3 172/4885PTK2 365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.