Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MET | P08581 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13859954 | 0.87 | CYP3A4 (0.53) | CYP3A4MAPTKDM4EMETLMNA | |
| SCHEMBL2409389 | 0.86 | CYP3A4 (0.66) | CYP3A4MAPTKDM4ELMNAIKBKE | |
| SCHEMBL29569185 | 0.86 | CYP3A4 (0.66) | CYP3A4MAPTKDM4ELMNAIKBKE | |
| SCHEMBL2451554 | 0.82 | CYP3A4 (0.71) | CYP3A4MAPTKDM4EMETLMNA | |
| SCHEMBL13859948 | 0.82 | IMPDH2 (0.50) | CYP3A4KDM4ELMNAMAPK14NCOA1 | |
| SCHEMBL13859959 | 0.82 | MAPT (0.71) | CYP3A4MAPTKDM4EMETLMNA | |
| SCHEMBL13859956 | 0.81 | MAPT (0.50) | CYP3A4MAPTKDM4EMETLMNA | |
| SCHEMBL13629319 | 0.81 | KDM4C (0.47) | MAPTKDM4EMETIKBKENCOA1 | |
| SCHEMBL6387637 | 0.80 | KDM4E (0.50) | CYP3A4KDM4ELMNAMAPK14CDK4 | |
| SCHEMBL13859944 | 0.78 | CDK5 (0.39) | CYP3A4KDM4ELMNANCOA1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951252-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007050383-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |
| US-20090131423-A1 | Tyrosine Kinase Inhibitors | MERCK & CO., INC. (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090131423-A1 | Tyrosine Kinase Inhibitors | MERCK & CO., INC. (US) | 2009-05-21 | — | — | US | disclosed |
| WO-2007050383-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131423-A1 | Tyrosine Kinase Inhibitors | ABL1, ERBB2, MET | CYP3A4 4606/4885MAPT 2557/4885KDM4E 958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.