Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.35 |
| ▸ | TYMP | P19971 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | POLA1 | P09884 | 1/20 | 0.32 |
| ▸ | POLG | P54098 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14645672 | 1.00 | FGFR1 (0.54) | FGFR1SLC22A6NT5EHPRT1TYMP | |
| SCHEMBL5280050 | 0.86 | FGFR1 (0.57) | FGFR1SLC22A6NT5EHPRT1TYMP | |
| SCHEMBL28677450 | 0.85 | FGFR1 (0.54) | FGFR1SLC22A6NT5EHPRT1TYMP | |
| SCHEMBL8896084 | 0.81 | FGFR1 (0.55) | FGFR1SLC22A6NT5EHPRT1TYMP | |
| SCHEMBL16037340 | 0.81 | FGFR1 (0.55) | FGFR1SLC22A6NT5EHPRT1TYMP | |
| SCHEMBL3374447 | 0.80 | CYP3A4 (0.39) | FGFR1SLC22A6HPRT1TYMPCYP3A4 | |
| SCHEMBL8895343 | 0.80 | FGFR1 (0.54) | FGFR1SLC22A6NT5EHPRT1TYMP | |
| SCHEMBL7262522 | 0.76 | FGFR1 (0.72) | FGFR1SLC22A6HPRT1TYMPCYP3A4 | |
| SCHEMBL7262516 | 0.76 | FGFR1 (0.72) | FGFR1SLC22A6HPRT1TYMPCYP3A4 | |
| SCHEMBL28796542 | 0.75 | FGFR1 (0.54) | FGFR1SLC22A6NT5EHPRT1TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1909578-A2 | HIV INTEGRASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-04-16 | — | — | EP | claimed |
| WO-2007019130-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | claimed |