Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 14/20 | 0.68 |
| ▸ | CNR1 | P21554 | 7/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.60 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347589 | 0.91 | CNR2 (0.69) | CNR2CNR1ALDH1A1 | |
| SCHEMBL9029183 | 0.89 | LMNA (0.68) | CNR2CNR1 | |
| SCHEMBL11903673 | 0.89 | CNR2 (0.74) | CNR2CNR1 | |
| SCHEMBL31052987 | 0.89 | CNR2 (0.74) | CNR2CNR1 | |
| SCHEMBL30373303 | 0.87 | NR4A2 (0.69) | ALDH1A1MAPTCREBBPPLK1 | |
| SCHEMBL2429622 | 0.87 | NR4A2 (0.69) | ALDH1A1MAPTCREBBPPLK1 | |
| SCHEMBL12168491 | 0.85 | CNR2 (0.65) | CNR2CNR1ALDH1A1MAPTCREBBP | |
| SCHEMBL30384771 | 0.85 | CNR2 (0.65) | CNR2CNR1ALDH1A1MAPTCREBBP | |
| SCHEMBL12643131 | 0.84 | PLK1 (0.65) | CNR2CNR1ALDH1A1MAPTCREBBP | |
| SCHEMBL17885854 | 0.83 | ALDH1A1 (0.70) | CNR2CNR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945217-A2 | COMBINATIONS COMPRISING A VEGF RECEPTOR INHIBITOR AND A PENETRATION ENHANCER | Novartis AG (CH) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007031265-A2 | COMBINATIONS COMPRISING A VEGF RECEPTOR INHIBITOR AND A PENETRATION ENHANCER | NOVARTIS AG (CH) | 2007-03-22 | — | — | WO | disclosed |
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |
| US-5552398-A | TREATMENT OF IRRITABLE BOWEL DIARRHEA | SMITHKLINE BEECHAM P.L.C. (GB) | 1996-09-03 | — | — | US | disclosed |
| EP-0603220-A1 | AZABICYCLIC COMPOUNDS AS 5-HT 4? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-06-29 | — | — | EP | disclosed |
| WO-1993005040-A1 | AZABICYCLIC COMPOUNDS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-03-18 | — | — | WO | disclosed |