Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 19/20 | 0.82 |
| ▸ | NQO2 | P16083 | 2/20 | 0.82 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.82 |
| ▸ | F10 | P00742 | 1/20 | 0.82 |
| ▸ | PLG | P00747 | 1/20 | 0.82 |
| ▸ | PLAT | P00750 | 1/20 | 0.82 |
| ▸ | PROC | P04070 | 1/20 | 0.82 |
| ▸ | HPN | P05981 | 1/20 | 0.82 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.82 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.82 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.82 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.82 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.82 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13562741 | 0.95 | F2 (0.79) | F2NQO2SLC22A2F10PLG | |
| SCHEMBL28404491 | 0.90 | F2 (0.91) | F2NQO2SLC22A2F10PLG | |
| Dabigatran SCHEMBL30038681 | 0.90 | F2 (1.00) | F2NQO2SLC22A2F10PLG | |
| Dabigatran SCHEMBL3573 | 0.90 | F2 (1.00) | F2NQO2SLC22A2F10PLG | |
| Dabigatran SCHEMBL29582891 | 0.90 | F2 (1.00) | F2NQO2SLC22A2F10PLG | |
| SCHEMBL14903585 | 0.90 | F2 (0.89) | F2NQO2SLC22A2F10PLG | |
| Dabigatran SCHEMBL15152349 | 0.90 | F2 (0.98) | F2NQO2SLC22A2F10PLG | |
| Dabigatran SCHEMBL21768719 | 0.90 | F2 (0.98) | F2NQO2SLC22A2F10PLG | |
| Dabigatran SCHEMBL29045198 | 0.90 | F2 (0.98) | F2NQO2SLC22A2F10PLG | |
| Dabigatran SCHEMBL27982835 | 0.90 | F2 (0.98) | F2NQO2SLC22A2F10PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3195876-A1 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-07-26 | — | — | EP | disclosed |
| EP-2525812-B1 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INT (DE) | 2017-01-18 | — | — | EP | disclosed |
| US-20150210778-A1 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INT (DE) | 2015-07-30 | — | — | US | disclosed |
| US-20150210778-A1 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INT (DE) | 2015-07-30 | — | — | US | disclosed |
| US-9034822-B2 | Methods of using antibodies during anticoagulant therapy of dabigatran and/or related compounds | BOEHRINGER IGELHEIM INTERNATIONAL GMBH (DE) | 2015-05-19 | — | — | US | disclosed |
| US-20140377265-A1 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-12-25 | — | — | US | disclosed |
| US-8821871-B2 | Anticoagulant antidotes comprising antibodies that bind dabigatran and/or related compounds and methods of use thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-02 | — | — | US | disclosed |
| US-20130289248-A1 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| US-8486398-B2 | Anticoagulant antidotes comprising antibodies that bind dabigatran and/or related compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-16 | — | — | US | disclosed |
| US-20120276123-A1 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-01 | — | — | US | disclosed |
| WO-2012130834-A1 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |
| US-20120027780-A1 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-02 | — | — | US | disclosed |
| US-20120027780-A1 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-02 | — | — | US | disclosed |
| WO-2011089183-A2 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-28 | — | — | WO | disclosed |
| WO-2011089183-A2 | ANTICOAGULANT ANTIDOTES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210778-A1 | ANTICOAGULANT ANTIDOTES | SERPINC1, KCNH1, ANTXR2 | F2 6/4885NQO2 810/4885SLC22A2 3620/4885 |
| US-20120027780-A1 | ANTICOAGULANT ANTIDOTES | SERPINC1, KCNH1, ANTXR2 | F2 6/4885NQO2 810/4885SLC22A2 3620/4885 |
| US-20140377265-A1 | ANTICOAGULANT ANTIDOTES | SERPINC1, KCNH1, ANTXR2 | F2 6/4885NQO2 810/4885SLC22A2 3620/4885 |
| US-20130289248-A1 | ANTICOAGULANT ANTIDOTES | SERPINC1, KCNH1, ANTXR2 | F2 6/4885NQO2 810/4885SLC22A2 3620/4885 |
| US-20120276123-A1 | ANTICOAGULANT ANTIDOTES | SERPINC1, KCNH1, ANTXR2 | F2 6/4885NQO2 810/4885SLC22A2 3620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.