Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.33 |
| ▸ | DRD3 | P35462 | 7/20 | 0.33 |
| ▸ | DRD4 | P21917 | 5/20 | 0.33 |
| ▸ | DRD1 | P21728 | 3/20 | 0.33 |
| ▸ | DRD5 | P21918 | 3/20 | 0.33 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
| ▸ | BRD1 | O95696 | 1/20 | 0.31 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 1/20 | 0.30 |
| ▸ | STS | P08842 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506497 | 0.89 | SLC2A1 (0.36) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL1506583 | 0.76 | SLC2A1 (0.39) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL8206659 | 0.73 | NOTUM (0.40) | KDM4EALDH1A1 | |
| SCHEMBL7107742 | 0.69 | DRD2 (0.36) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL7711897 | 0.69 | HTT (0.38) | KDM4EALDH1A1 | |
| SCHEMBL12533716 | 0.69 | STS (0.36) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL1506403 | 0.66 | STS (0.34) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL5026108 | 0.66 | STS (0.64) | DRD2DRD3HTR1DSTSALDH1A1 | |
| SCHEMBL21468494 | 0.66 | PTPN1 (0.40) | KDM4ESTSALDH1A1 | |
| SCHEMBL10157971 | 0.66 | DRD2 (0.34) | DRD2DRD3DRD4DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971595-A2 | CETP INHIBITORS | Merck & Co., Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007081569-A2 | CETP INHIBITORS | MERCK & CO., INC. (US) | 2007-07-19 | — | — | WO | disclosed |