Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.39 |
| ▸ | MST1R | Q04912 | 3/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | FECH | P22830 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4313185 | 0.90 | RET (0.42) | — | |
| SCHEMBL13859978 | 0.89 | PDE10A (0.40) | METMST1REGLN1CYP3A4CYP2D6 | |
| SCHEMBL4308766 | 0.83 | MTOR (0.43) | METMST1RCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4313284 | 0.81 | MET (0.44) | METMST1R | |
| SCHEMBL4308952 | 0.80 | MET (0.57) | METMST1RCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4312490 | 0.76 | MET (0.45) | METMST1REGLN1CYP3A4CYP2D6 | |
| SCHEMBL2443780 | 0.73 | CCND3 (0.43) | MET | |
| SCHEMBL2453543 | 0.73 | MET (0.42) | METMST1R | |
| SCHEMBL2449131 | 0.73 | MET (0.47) | METMST1R | |
| SCHEMBL2445635 | 0.70 | MET (0.50) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951252-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007050383-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |