Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 9/20 | 0.37 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR7 | P34969 | 4/20 | 0.36 |
| ▸ | HTR1D | P28221 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4238081 | 0.66 | BACE1 (0.59) | TAAR1HTR5AHDAC4GRIN1GRIN2A | |
| SCHEMBL30344664 | 0.61 | HDAC4 (0.43) | TAAR1HDAC4GRIN1GRIN2ATSHR | |
| SCHEMBL1604324 | 0.61 | HDAC4 (0.43) | TAAR1HDAC4GRIN1GRIN2ATSHR | |
| SCHEMBL4284969 | 0.60 | TAAR1 (0.35) | TAAR1HTR5AHTR1AHTR2CHTR7 | |
| SCHEMBL3607239 | 0.60 | TAAR1 (1.00) | TAAR1 | |
| SCHEMBL3607237 | 0.60 | TAAR1 (1.00) | TAAR1 | |
| SCHEMBL3611849 | 0.60 | TAAR1 (1.00) | TAAR1 | |
| SCHEMBL31506444 | 0.60 | LMNA (0.45) | TAAR1HDAC4GRIN1GRIN2ATSHR | |
| Hydrochloric Acid SCHEMBL2364251 | 0.59 | HDAC4 (0.42) | TAAR1HDAC4GRIN1GRIN2ATSHR | |
| SCHEMBL23647453 | 0.58 | ADRB1 (0.40) | HTR2CHTR2AHDAC4GRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954682-A1 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER S DISEASE, NEURODEGENERATION AND DEMENTIA | Astra Zeneca AB (SE) | 2008-08-13 | — | — | EP | claimed |
| WO-2007058601-A1 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | claimed |