Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.44 |
| ▸ | FLT1 | P17948 | 3/20 | 0.38 |
| ▸ | FLT4 | P35916 | 3/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2709327 | 0.84 | KMO (0.37) | KDRFLT1FLT4KMO | |
| SCHEMBL5068344 | 0.80 | KDR (0.44) | KDRFLT1FLT4KMORET | |
| SCHEMBL7790214 | 0.79 | HAO1 (0.47) | KDRKMO | |
| SCHEMBL273192 | 0.79 | KDR (0.55) | KDRFLT1FLT4KMORET | |
| SCHEMBL272878 | 0.79 | KDR (0.55) | KDRFLT1FLT4KMORET | |
| SCHEMBL2707079 | 0.78 | KDR (0.54) | KDRFLT1FLT4KMORET | |
| SCHEMBL2707082 | 0.78 | KDR (0.56) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2780055 | 0.73 | ALDH1A1 (0.50) | KDRKMOKITMET | |
| SCHEMBL692108 | 0.71 | CYP1A2 (0.53) | KMOL3MBTL1MAP4K4 | |
| SCHEMBL21178150 | 0.71 | CYP1A2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945217-A2 | COMBINATIONS COMPRISING A VEGF RECEPTOR INHIBITOR AND A PENETRATION ENHANCER | Novartis AG (CH) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007031265-A2 | COMBINATIONS COMPRISING A VEGF RECEPTOR INHIBITOR AND A PENETRATION ENHANCER | NOVARTIS AG (CH) | 2007-03-22 | — | — | WO | disclosed |