SCHEMBL5068366

SCHEMBL5068366

O=C(Nc1ccc(Cl)cn1)c1cc2ccccc2cc1NC(=O)C1CCC(N2CCCC2=O)CC1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 4/20 0.55
F10 P00742 12/20 0.52
MEN1 O00255 1/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
KMT2A Q03164 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
LMNA P02545 1/20 0.45
TP53 P04637 1/20 0.45
GAA P10253 1/20 0.45
TSHR P16473 1/20 0.45
PTBP1 P26599 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5068364 1.00 NPY5R (0.55) NPY5RF10MEN1NPC1RAB9A
SCHEMBL14191248 0.90 F10 (0.65) NPY5RF10
SCHEMBL14191250 0.90 F10 (0.57) NPY5RF10LMNATP53GAA
SCHEMBL14191249 0.87 F10 (0.59) NPY5RF10
SCHEMBL14191247 0.86 F10 (0.56) NPY5RF10
SCHEMBL5071102 0.85 NPY5R (0.55) NPY5RF10MEN1KMT2ATSHR
SCHEMBL5071105 0.85 NPY5R (0.55) NPY5RF10MEN1KMT2ATSHR
SCHEMBL14191275 0.84 NPY5R (0.55) NPY5RF10NPC1RAB9ALMNA
SCHEMBL14191313 0.83 NPY5R (0.54) NPY5RF10RAB9ALMNATSHR
SCHEMBL14191279 0.82 NPY5R (0.53) NPY5RF10LMNATSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7375119-B2 Amide type carboxamide derivative MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-05-20 US disclosed
US-20060287329-A1 Amide type carboxamide derivative MITSUBISHI TANABE PHARMA CORPORATION (JP) 2006-12-21 US disclosed
EP-1666455-A1 AMIDE TYPE CARBOXAMIDE DERIVATIVE TANABE SEIYAKU CO., LTD. (JP) 2006-06-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060287329-A1 Amide type carboxamide derivative F12, F11, F13A1 NPY5R 42/4885F10 7/4885MEN1 1337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.