SCHEMBL5071102

SCHEMBL5071102

O=C(Nc1ccc(Cl)cn1)c1ccc(C(F)(F)F)cc1NC(=O)[C@H]1CC[C@H](N2CCCC2=O)CC1

nearest known ligand 0.55

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 5/20 0.55
F10 P00742 11/20 0.48
CCRL2 O00421 1/20 0.43
MEN1 O00255 1/20 0.42
TSHR P16473 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5071105 1.00 NPY5R (0.55) NPY5RF10CCRL2MEN1TSHR
SCHEMBL5067472 0.88 F10 (0.46) NPY5RF10
SCHEMBL5067475 0.88 F10 (0.46) NPY5RF10
SCHEMBL14191250 0.86 F10 (0.57) NPY5RF10TSHR
SCHEMBL14191248 0.86 F10 (0.65) NPY5RF10
SCHEMBL5068366 0.85 NPY5R (0.55) NPY5RF10MEN1TSHRKMT2A
SCHEMBL5068364 0.85 NPY5R (0.55) NPY5RF10MEN1TSHRKMT2A
SCHEMBL14191249 0.83 F10 (0.59) NPY5RF10
SCHEMBL14191247 0.81 F10 (0.56) NPY5RF10
SCHEMBL14191275 0.80 NPY5R (0.55) NPY5RF10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7375119-B2 Amide type carboxamide derivative MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-05-20 US disclosed
US-7375119-B2 Amide type carboxamide derivative MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-05-20 US disclosed
US-7375119-B2 Amide type carboxamide derivative MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-05-20 US disclosed
US-20060287329-A1 Amide type carboxamide derivative MITSUBISHI TANABE PHARMA CORPORATION (JP) 2006-12-21 US disclosed
EP-1666455-A1 AMIDE TYPE CARBOXAMIDE DERIVATIVE TANABE SEIYAKU CO., LTD. (JP) 2006-06-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060287329-A1 Amide type carboxamide derivative F12, F11, F13A1 NPY5R 42/4885F10 7/4885CCRL2 3338/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.