SCHEMBL5068397

CCCCCCCC(=O)N(C(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CN)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(N)=O

nearest known ligand 0.54

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	F2	P00734	4/20	0.54

▸	APLNR	P35414	3/20	0.53

▸	GHSR	Q92847	4/20	0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4464636	0.95	APLNR (0.54)	F2APLNRGHSR
SCHEMBL4459179	0.91	APLNR (0.63)	F2APLNRGHSR
SCHEMBL5068412	0.91	APLNR (0.60)	APLNRGHSR
SCHEMBL5059932	0.91	APLNR (0.64)	F2APLNRGHSR
SCHEMBL16150700	0.89	APLNR (0.64)	APLNRGHSR
SCHEMBL7053513	0.88	NMUR2 (0.47)	F2APLNR
SCHEMBL6955243	0.84	F2 (0.55)	F2APLNRGHSR
SCHEMBL30166497	0.84	APLNR (0.62)	APLNRGHSR
SCHEMBL5554051	0.83	ACE (0.48)	—
SCHEMBL7619215	0.82	NMUR2 (0.58)	APLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20080269116-A1	Methods of Inhibiting Proinflammatory Cytokine Expression Using Ghrelin	TAUB DENNIS D	2008-10-30	—	—	US	disclosed
EP-1750745-A1	METHODS OF INHIBITING PROINFLAMMATORY CYTOKINE EXPRESSION USING GHRELIN	The United States of America, represented by the Secretary, Department of Health and Human Services (US)	2007-02-14	—	—	EP	disclosed
WO-2005110463-A1	METHODS OF INHIBITING PROINFLAMMATORY CYTOKINE EXPRESSION USING GHRELIN	THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH (US)	2005-11-24	—	—	WO	disclosed