SCHEMBL5068702

SCHEMBL5068702

O=[N+]([O-])c1cc(-c2ccccc2)c([N+](=O)[O-])cc1Br

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.56
TDP1 Q9NUW8 1/20 0.56
CTSB P07858 1/20 0.47
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
MAPK1 P28482 2/20 0.43
CYP1A2 P05177 2/20 0.43
TP53 P04637 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
STAT6 P42226 1/20 0.43
HIF1A Q16665 1/20 0.43
PHLPP2 Q6ZVD8 1/20 0.43
HSD17B10 Q99714 1/20 0.43
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
HSP90AA1 P07900 1/20 0.42
PTGES O14684 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15461976 0.89 ALDH1A1 (0.69) ALDH1A1TDP1CRHBPCRHR2MAPK1
SCHEMBL5069290 0.85 TDP1 (0.51) ALDH1A1TDP1CTSBCRHBPCRHR2
SCHEMBL32662713 0.85 ALDH1A1 (0.51) ALDH1A1TDP1CTSBCRHBPCRHR2
SCHEMBL28827487 0.85 ALDH1A1 (0.51) ALDH1A1TDP1CTSBCRHBPCRHR2
SCHEMBL22007056 0.83 ALDH1A1 (0.67) ALDH1A1TDP1CRHBPCRHR2MAPK1
SCHEMBL8964813 0.82 ALDH1A1 (0.51) ALDH1A1TDP1CTSBCRHBPCRHR2
SCHEMBL29430733 0.79 ALDH1A1 (0.61) ALDH1A1TDP1CTSBCRHBPCRHR2
SCHEMBL100456 0.79 ALDH1A1 (0.61) ALDH1A1TDP1CTSBCRHBPCRHR2
SCHEMBL15790413 0.79 ALDH1A1 (0.61) ALDH1A1TDP1CTSBCRHBPCRHR2
SCHEMBL9452645 0.78 ALDH1A1 (0.52) ALDH1A1CTSBMAPK1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1319231-A4 PROGRAMMABLE MOLECULAR DEVICE UNIV WM MARSH RICE (US) 2008-11-19 EP disclosed
CN-1535466-A Programmable molecular device WM����ʲ��˹��ѧ 2004-10-06 CN disclosed
EP-1319231-A1 PROGRAMMABLE MOLECULAR DEVICE Wm. MARSH RICE UNIVERSITY (US) 2003-06-18 EP disclosed
US-20030058697-A1 Programmable molecular device NAVY, SECRETARY OF THE, UNITED STATES OF AMERICA OFFICE OF NAVAL RESEARCH 2003-03-27 US disclosed
WO-2002009117-A1 PROGRAMMABLE MOLECULAR DEVICE WM. MARSH RICE UNIVERSITY (US) 2002-01-31 WO disclosed