SCHEMBL50688

SCHEMBL50688

NS(=O)(=O)c1cccc2cccnc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 1.00
CA1 P00915 2/20 1.00
CA2 P00918 2/20 1.00
CA9 Q16790 2/20 1.00
KDM4E B2RXH2 4/20 0.62
GAA P10253 4/20 0.62
MAPT P10636 3/20 0.62
APOBEC3G Q9HC16 2/20 0.62
NPSR1 Q6W5P4 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
ALOX12 P18054 1/20 0.58
ALDH1A1 P00352 2/20 0.57
CA12 O43570 1/20 0.56
CA14 Q9ULX7 1/20 0.56
AKT1 P31749 1/20 0.56
KMT2A Q03164 4/20 0.55
MEN1 O00255 3/20 0.54
TSHR P16473 2/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
HTT P42858 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29470241 1.00 MAPK1 (1.00) MAPK1CA1CA2CA9KDM4E
SCHEMBL3256397 0.84 CA1 (0.73) MAPK1CA1CA2CA9KDM4E
SCHEMBL7180056 0.82 MAPK1 (0.70) MAPK1CA1CA2CA9KDM4E
SCHEMBL27592567 0.82 MAPK1 (0.70) MAPK1CA1CA2CA9KDM4E
SCHEMBL3780950 0.82 GAA (0.76) MAPK1CA1CA2CA9GAA
SCHEMBL4617096 0.81 MAPK1 (0.68) MAPK1CA1CA2CA9KDM4E
SCHEMBL2459763 0.81 MAPK1 (0.68) MAPK1CA1CA2CA9KDM4E
SCHEMBL51046 0.81 MAPK1 (0.68) MAPK1CA1CA2CA9KDM4E
SCHEMBL11679037 0.81 MAPK1 (0.68) MAPK1CA1CA2CA9KDM4E
SCHEMBL863061 0.81 MAPK1 (0.68) MAPK1CA1CA2CA9KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 242 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117285461-A 8-quinoline sulfonamide-3 g derivative and application thereof 安徽医科大学 2023-12-26 CN claimed
EP-3307271-B1 METHODS OF USING PYRUVATE KINASE ACTIVATORS AGIOS PHARMACEUTICALS INC (US) 2023-09-13 EP claimed
CN-114874138-B 8-quinoline sulfonamide compound and application thereof 安徽瀚海博兴生物技术有限公司 2023-06-09 CN claimed
EP-3898588-B1 DISUBSTITUTED ALKYNE DERIVATIVES MERCK PATENT GMBH (DE) 2023-01-11 EP claimed
CN-114874138-A 8-quinoline sulfonamide compound and application thereof 安徽瀚海博兴生物技术有限公司 2022-08-09 CN claimed
CN-105732624-B The preparation method and its usage of pyrroles [4,3,2-de] quinoline -2 (1H) -one class BRD4 protein inhibitor 中国药科大学 2019-08-02 CN claimed
CN-107847493-A ANTITUSSIVE COMPOSITIONS AND METHODS 阿提努公司 2018-03-27 CN claimed
CN-105732624-A Preparation method and application of pyrrole [4,3,2-de] quinoline-2-(1H)-ketone BRD4 protein inhibitor 中国药科大学 2016-07-06 CN claimed
CN-105267897-A Traditional Chinese medicine composition for treating cancer osseous metastasis CHEN GUOJUN 2016-01-27 CN claimed
CN-103384662-A Novel 1, 2-bis-sulfonamide derivatives as chemokine receptor modulators ALLERGAN INC 2013-11-06 CN claimed
CN-1784230-A Positive modulators of nicotinic acetylcholine receptors ASTRAZENECA AB (SE) 2006-06-07 CN claimed
EP-1328269-A2 ASSOCIATION OF THE CB1 RECEPTOR ANTAGONIST AND A SIBUTRAMIN FOR TREATING OBESITY Aventis Pharma S.A. (FR) 2003-07-23 EP claimed
WO-2002028346-A2 ASSOCIATION OF THE CB1 RECEPTOR ANTAGONIST AND SIBUTRAMIN, FOR TREATING OBESITY AVENTIS PHARMA S.A. (FR) 2002-04-11 WO claimed
EP-0682663-B1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS UPJOHN CO (US) 2001-04-18 EP claimed
US-5977169-A FOR TREATMENT OF A PERSON WITH AIDS OR AIDS RELATED DISEASES PHARMACIA & UPJOHN COMPANY 1999-11-02 US claimed
US-5686486-A 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful to treat retroviral infections PHARMACIA & UPJOHN COMPANY (US) 1997-11-11 US claimed
EP-0720607-A1 SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES PHARMACIA & UPJOHN COMPANY (US) 1996-07-10 EP claimed
EP-0682663-A1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS PHARMACIA & UPJOHN COMPANY (US) 1995-11-22 EP claimed
WO-1995007901-A1 SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES THE UPJOHN COMPANY (US) 1995-03-23 WO claimed
WO-1994018188-A1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL[B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS THE UPJOHN COMPANY (US) 1994-08-18 WO claimed