Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.73 |
| ▸ | CA2 | P00918 | 4/20 | 0.73 |
| ▸ | CA9 | Q16790 | 3/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.49 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28168756 | 0.85 | CA1 (0.60) | CA1CA2CA9MAPK1KDM4E | |
| SCHEMBL50688 | 0.84 | MAPK1 (1.00) | CA1CA2CA9MAPK1KDM4E | |
| SCHEMBL29470241 | 0.84 | MAPK1 (1.00) | CA1CA2CA9MAPK1KDM4E | |
| SCHEMBL28476864 | 0.84 | MAPK1 (0.54) | CA1CA2CA9MAPK1KDM4E | |
| SCHEMBL28348888 | 0.84 | KDM4E (0.54) | CA1CA2CA9MAPK1KDM4E | |
| SCHEMBL3269489 | 0.81 | CA1 (0.50) | CA1CA2CA9MAPK1KDM4E | |
| SCHEMBL12853981 | 0.78 | LMNA (0.68) | CA1CA2CA9MAPK1KDM4E | |
| SCHEMBL1282008 | 0.78 | CCR1 (0.75) | CA1CA2CA9MAPK1KDM4E | |
| SCHEMBL30184687 | 0.78 | CCR1 (0.75) | CA1CA2CA9MAPK1KDM4E | |
| Sulfuric Acid SCHEMBL28678534 | 0.77 | KDM4E (0.73) | CA1CA2CA9MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675526-A1 | NOVEL SULFONAMINOQUINOLINE HEPCIDIN ANTAGONISTS | Vifor (International) AG (CH) | 2013-12-25 | — | — | EP | disclosed |
| WO-2012110603-A1 | NOVEL SULFONAMINOQUINOLINE HEPCIDIN ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-23 | — | — | WO | disclosed |
| WO-2010051064-A1 | COMPOUNDS THAT INHIBIT NFκB ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2010-05-06 | — | — | WO | disclosed |
| US-7183320-B2 | Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents | ELI LILLY AND COMPANY (US) | 2007-02-27 | — | — | US | disclosed |