Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3370759 | 0.78 | AGER (0.55) | AGERCHRM2CHRM3OPRM1CTSD | |
| SCHEMBL5913502 | 0.76 | HSD11B1 (0.47) | AGERCHRM2CHRM3OPRM1SLC6A2 | |
| SCHEMBL3373057 | 0.74 | AGER (0.58) | AGERCHRM2CHRM3OPRM1CTSD | |
| SCHEMBL736913 | 0.72 | AGER (0.50) | AGERCHRM2CHRM3OPRM1CTSD | |
| SCHEMBL736914 | 0.72 | AGER (0.50) | AGERCHRM2CHRM3OPRM1CTSD | |
| SCHEMBL18586065 | 0.72 | HDAC8 (0.43) | AGERCHRM2CHRM3OPRM1SLC6A2 | |
| SCHEMBL17506917 | 0.72 | MC4R (0.49) | AGERCHRM2CHRM3OPRM1CTSD | |
| SCHEMBL1700010 | 0.72 | MC4R (0.49) | AGERCHRM2CHRM3OPRM1CTSD | |
| SCHEMBL1069848 | 0.72 | SLC6A2 (0.42) | AGERCHRM2CHRM3OPRM1SLC6A2 | |
| SCHEMBL77425 | 0.71 | MC4R (0.54) | AGERCHRM2CHRM3OPRM1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910272-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009250-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-01-25 | — | — | WO | disclosed |