Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 8/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203719 | 0.85 | LSS (0.71) | LSSLMNACNR2ALDH1A1MEN1 | |
| SCHEMBL4804990 | 0.83 | LSS (0.70) | LSS | |
| SCHEMBL4804999 | 0.83 | LSS (0.70) | LSS | |
| SCHEMBL6529024 | 0.81 | GBA1 (0.43) | LMNACNR2ALDH1A1MEN1CYP2C9 | |
| SCHEMBL5068898 | 0.81 | GBA1 (0.43) | LMNACNR2ALDH1A1MEN1CYP2C9 | |
| SCHEMBL6447874 | 0.81 | LSS (0.51) | LSSALDH1A1MEN1KMT2A | |
| SCHEMBL4804150 | 0.77 | LSS (0.67) | LSS | |
| SCHEMBL4804159 | 0.77 | LSS (0.67) | LSS | |
| SCHEMBL6018504 | 0.76 | LSS (0.55) | LSS | |
| SCHEMBL6018501 | 0.76 | LSS (0.55) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-B1 | AMINOCYCLOHEXANE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-08-06 | — | — | EP | disclosed |