Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 5/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL661830 | 0.82 | MAPT (0.48) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL662977 | 0.81 | MAPT (0.47) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL662025 | 0.81 | MAPT (0.47) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL662083 | 0.77 | MAPT (0.43) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL662629 | 0.76 | MAPT (0.43) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL8407758 | 0.74 | MAPT (0.42) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL17087123 | 0.71 | MAPT (0.53) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL2799797 | 0.71 | MAPT (0.53) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL65612 | 0.70 | MAPT (0.51) | MAPTL3MBTL1HPGDMAPK1TDP1 | |
| SCHEMBL660641 | 0.70 | MAPT (0.51) | MAPTL3MBTL1HPGDMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910272-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009250-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-01-25 | — | — | WO | disclosed |